IFITM 2 (11p15.59, DSPA2c, 1-8D

Also known as

1-8D; DSPA2c

Expression

Ubiquitous expression in appendix (RPKM 262.7), spleen (RPKM 209.9) and 23 other tissues See more

 

Preferred Names

interferon-induced transmembrane protein 2

Names

dispanin subfamily A member 2c

interferon-inducible protein 1-8D

 

1. Δ20 IFITM2 differentially restricts X4 and R5 HIV-1. Wu WL, et al. Proc Natl Acad Sci U S A, 2017 Jul 3. PMID 28630320, Free PMC Article
2. The human 1-8D gene (IFITM2) is a novel p53 independent pro-apoptotic gene. Daniel-Carmi V, et al. Int J Cancer, 2009 Dec 15. PMID 19544527
3. pH Optimum of Hemagglutinin-Mediated Membrane Fusion Determines Sensitivity of Influenza A Viruses to the Interferon-Induced Antiviral State and IFITMs. Gerlach T, et al. J Virol, 2017 Jun 1. PMID 28356532, Free PMC Article
4. Differential regulation of interferon-induced mRNAs and c-myc mRNA by alpha- and gamma-interferons. Kelly JM, et al. Eur J Biochem, 1985 Dec 2. PMID 3935435
5. Molecular analysis of a human interferon-inducible gene family. Lewin AR, et al. Eur J Biochem, 1991 Jul 15. PMID 1906403

See all (38) citations in PubMed

1. These studies identify a novel role for IFITM1, 2, and 3 in inhibiting HIV replication at the level of translation.
2. overexpression of IFITM1, 2 and 3 suppressed entry of CXCR4 and CCR5 tropic viruses; entry of transmitted founder HIV-1 in U87 cells is more sensitive to inhibition by IFITM2 and IFITM3 than by IFITM1
3. Delta20 IFITM2 may serve as a major contributor to the gatekeeping mechanism that explains restriction of X4 viruses in the early stage of HIV-1 infection
4. These results indicate that IFITM2 protein can restrict alphavirus infection by inhibiting viral fusion with cellular membranes.
5. The transcriptional regulation of IFITM1, 2 and 3 expression.
6. IFITM2 promotes gastric cancer growth and metastasis via IGF1/IGF1R/STAT3 signaling pathway.
7. findings show that the sensitivity of influenza A viruses to the IFN-induced antiviral state and IFITM2 and IFITM3 proteins depends on the pH value at which the viral HA undergoes a conformational transition and mediates membrane fusion
8. IFITM2 and IFITM3 specifically antagonize the HIV-1 envelope glycoprotein (Env), thereby inhibiting viral infection.
9. propose that the IFITM proteins act in a coordinated manner to restrict HCV infection by targeting the endocytosed HCV virion for lysosomal degradation and demonstrate that the actions of the IFITM proteins are indeed virus and cell-type specific
10. G3BP1, G3BP2 and CAPRIN1 are required for translation of interferon stimulated mRNAs and are targeted by a dengue virus non-coding RNA.