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fredag 13 mars 2020

SARS CoV Orf 1a

https://www.ncbi.nlm.nih.gov/protein/NP_828850.1

orf1a polyprotein (pp1a) [Severe acute respiratory syndrome-related coronavirus]

NCBI Reference Sequence: NP_828850.1

LOCUS       NP_828850               4382 aa            linear   VRL 13-AUG-2018
DEFINITION  orf1a polyprotein (pp1a) [Severe acute respiratory syndrome-related
            coronavirus].
ACCESSION   NP_828850
VERSION     NP_828850.1
DBLINK      BioProject: PRJNA485481
DBSOURCE    REFSEQ: accession NC_004718.3
KEYWORDS    RefSeq.
SOURCE      Severe acute respiratory syndrome-related coronavirus
  ORGANISM  Severe acute respiratory syndrome-related coronavirus
            Viruses; Riboviria; Nidovirales; Cornidovirineae; Coronaviridae;
            Orthocoronavirinae; Betacoronavirus; Sarbecovirus.
REFERENCE   1  (residues 1 to 4382)
  AUTHORS   He,R., Dobie,F., Ballantine,M., Leeson,A., Li,Y., Bastien,N.,
            Cutts,T., Andonov,A., Cao,J., Booth,T.F., Plummer,F.A., Tyler,S.,
            Baker,L. and Li,X.
  CONSRTM   BCCA Genome Sciences Centre, British Columbia Centre for Disease
            Control and National Microbiology Laboratory Canada
  TITLE     Analysis of multimerization of the SARS coronavirus nucleocapsid
            protein
  JOURNAL   Biochem. Biophys. Res. Commun. 316 (2), 476-483 (2004)
   PUBMED   15020242
REFERENCE   2  (residues 1 to 4382)
  AUTHORS   Snijder,E.J., Bredenbeek,P.J., Dobbe,J.C., Thiel,V., Ziebuhr,J.,
            Poon,L.L., Guan,Y., Rozanov,M., Spaan,W.J. and Gorbalenya,A.E.
  TITLE     Unique and conserved features of genome and proteome of
            SARS-coronavirus, an early split-off from the coronavirus group 2
            lineage
  JOURNAL   J. Mol. Biol. 331 (5), 991-1004 (2003)
   PUBMED   12927536
REFERENCE   3  (residues 1 to 4382)
  AUTHORS   Marra,M.A., Jones,S.J., Astell,C.R., Holt,R.A., Brooks-Wilson,A.,
            Butterfield,Y.S., Khattra,J., Asano,J.K., Barber,S.A., Chan,S.Y.,
            Cloutier,A., Coughlin,S.M., Freeman,D., Girn,N., Griffith,O.L.,
            Leach,S.R., Mayo,M., McDonald,H., Montgomery,S.B., Pandoh,P.K.,
            Petrescu,A.S., Robertson,A.G., Schein,J.E., Siddiqui,A.,
            Smailus,D.E., Stott,J.M., Yang,G.S., Plummer,F., Andonov,A.,
            Artsob,H., Bastien,N., Bernard,K., Booth,T.F., Bowness,D., Czub,M.,
            Drebot,M., Fernando,L., Flick,R., Garbutt,M., Gray,M., Grolla,A.,
            Jones,S., Feldmann,H., Meyers,A., Kabani,A., Li,Y., Normand,S.,
            Stroher,U., Tipples,G.A., Tyler,S., Vogrig,R., Ward,D., Watson,B.,
            Brunham,R.C., Krajden,M., Petric,M., Skowronski,D.M., Upton,C. and
            Roper,R.L.
  TITLE     The Genome sequence of the SARS-associated coronavirus
  JOURNAL   Science 300 (5624), 1399-1404 (2003)
   PUBMED   12730501
REFERENCE   4  (residues 1 to 4382)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (31-AUG-2004) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   5  (residues 1 to 4382)
  CONSRTM   BCCA Genome Sciences Centre, British Columbia Centre for Disease
            Control and National Microbiology Laboratory Canada
  TITLE     Direct Submission
  JOURNAL   Submitted (30-APR-2003) Genome Sciences Centre, British Columbia
            Cancer Research Centre, 600 West 10th Avenue, Vancouver, BC V5Z
            4E6, Canada
  REMARK    Sequence update by submitter
REFERENCE   6  (residues 1 to 4382)
  CONSRTM   BCCA Genome Sciences Centre, British Columbia Centre for Disease
            Control and National Microbiology Laboratory Canada
  TITLE     Direct Submission
  JOURNAL   Submitted (23-APR-2003) Genome Sciences Centre, British Columbia
            Cancer Research Centre, 600 West 10th Avenue, Vancouver, BC V5Z
            4E6, Canada
  REMARK    Sequence update by submitter
REFERENCE   7  (residues 1 to 4382)
  CONSRTM   BCCA Genome Sciences Centre, British Columbia Centre for Disease
            Control and National Microbiology Laboratory Canada
  TITLE     Direct Submission
  JOURNAL   Submitted (13-APR-2003) Genome Sciences Centre, British Columbia
            Cancer Research Centre, 600 West 10th Avenue, Vancouver, BC V5Z
            4E6, Canada
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff.
            The annotation in based mainly on the sequence analysis described
            by Snijder et al. (2003). Annotation of transcription regulatory
            sequences was copied from virtually identical (except the very 3'
            end) AY291315 (Frankfurt 1).  Designations of the 3'-adjacent genes
            do not coincide with those provided by Marra et al. (2003).
            Method: conceptual translation.
FEATURES             Location/Qualifiers
     source          1..4382
                     /organism="Severe acute respiratory syndrome-related
                     coronavirus"
                     /isolate="Tor2"
                     /isolation_source="patient #2 with severe acute
                     respiratory syndrome (SARS)"
                     /db_xref="taxon:694009"
                     /country="Canada: Toronto"
    

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