Eräästä vuoden 2007 tavallisesta vuoden koronaviruksesta HKU1 S-piikkiproteiinin sekvenssitietoja

https://www.ncbi.nlm.nih.gov/protein/Q5MQD0.1
Tämän HKU1 viruksen  Spike on 1356 aminohappoa.

COMMENT 

[FUNCTION] Spike protein S1:  attaches the virion to the cell
            membrane by interacting with host receptor, initiating the
            infection. {ECO:0000255|HAMAP-Rule:MF_04099}.

 [FUNCTION] Spike protein S2: mediates fusion of the virion and
            cellular membranes by acting as a class I viral fusion protein.

 Under the current model, the protein has at least three
            conformational states: pre-fusion native state, pre-hairpin
            intermediate state, and post-fusion hairpin state. 

 During viral and  target cell membrane fusion, the coiled coil regions (heptad
            repeats) assume a trimer-of-hairpins structure, positioning the
            fusion peptide in close proximity to the C-terminal region of the
            ectodomain. The formation of this structure appears to drive
            apposition and subsequent fusion of viral and target cell
            membranes. {ECO:0000255|HAMAP-Rule:MF_04099}.

 [FUNCTION] Spike protein S2': Acts as a viral fusion peptide which
            is unmasked following S2 cleavage occurring upon virus endocytosis.
            {ECO:0000255|HAMAP-Rule:MF_04099}.

 [SUBUNIT] Homotrimer; each monomer consists of a S1 and a S2
            subunit.

 The resulting peplomers protrude from the virus surface as
            spikes. {ECO:0000255|HAMAP-Rule:MF_04099}.

 [SUBCELLULAR LOCATION] Virion membrane
            {ECO:0000255|HAMAP-Rule:MF_04099};

 Single-pass type I membrane  protein {ECO:0000255|HAMAP-Rule:MF_04099}.

 Host endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane
            {ECO:0000255|HAMAP-Rule:MF_04099}; 

Single-pass type I membrane protein {ECO:0000255|HAMAP-Rule:MF_04099}.

 Host cell membrane  {ECO:0000255|HAMAP-Rule:MF_04099}; Single-pass type I membrane
            protein {ECO:0000255|HAMAP-Rule:MF_04099}. 

Note=Accumulates in the  endoplasmic reticulum-Golgi intermediate compartment(ERGIC), where it
            participates in virus particle assembly. Some S oligomers are
            transported to the host plasma membrane (PM), where they may mediate
            cell-cell fusion. {ECO:0000255|HAMAP-Rule:MF_04099}.

 [PTM] Specific enzymatic cleavages in vivo yield mature proteins.
            The precursor is processed into S1 and S2 by host cell furin or
            another cellular protease to yield the mature S1 and S2 proteins.
            Additionally, a second cleavage leads to the release of a fusion
            peptide after viral attachment to host cell receptor.
            {ECO:0000255|HAMAP-Rule:MF_04099}.
            [PTM] The cytoplasmic Cys-rich domain is palmitoylated. Spike
            glycoprotein is digested within host endosomes.
            {ECO:0000255|HAMAP-Rule:MF_04099}.
            [MISCELLANEOUS] Isolate N1 belongs to genotype A.
            [SIMILARITY] Belongs to the betacoronaviruses spike protein family.
            {ECO:0000255|HAMAP-Rule:MF_04099}.
FEATURES             Location/Qualifiers
     source          1..1356