Leta i den här bloggen

torsdag 12 mars 2020

ERGIC-53 ja gp-virusproteiini. CoV tarvitsee propagoitumiseen ja infektiivisyyteen tätä isäntäsoluproteiinia


2013 Nov 13;14(5):522-34. doi: 10.1016/j.chom.2013.10.010.
Arenaviruses and hantaviruses cause severe human disease. Little is known regarding host proteins required for their propagation. We identified human proteins that interact with the glycoproteins (GPs) of a prototypic arenavirus and hantavirus and show that the lectin endoplasmic reticulum (ER)-Golgi intermediate compartment 53 kDa protein (ERGIC-53), a cargo receptor required for glycoprotein trafficking within the early exocytic pathway, associates with arenavirus, hantavirus, coronavirus, orthomyxovirus, and filovirus GPs. ERGIC-53 binds to arenavirus GPs through a lectin-independent mechanism, traffics to arenavirus budding sites, and is incorporated into virions. ERGIC-53 is required for arenavirus, coronavirus, and filovirus propagation; in its absence, GP-containing virus particles form but are noninfectious, due in part to their inability to attach to host cells. Thus, we have identified a class of pathogen-derived ERGIC-53 ligands, a lectin-independent basis for their association with ERGIC-53, and a role for ERGIC-53 in the propagation of several highly pathogenic RNA virus families.
Comment in
PMID:
24237698
PMCID:
PMC3999090
DOI:
10.1016/j.chom.2013.10.010
[Indexed for MEDLINE]
Free PMC Article

Inga kommentarer:

Skicka en kommentar