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onsdag 18 mars 2020

EBV:n osuus koronavirusinfektiossa?

2013 Jan 15;254(1-2):110-6. doi: 10.1016/j.jneuroim.2012.10.005. Epub 2012 Oct 26.

Epstein-Barr virus-induced gene 3 negatively regulates neuroinflammation and T cell activation following coronavirus-induced encephalomyelitis.

Epstein-Barr virus-induced gene 3 (EBI3) associates with p28 and p35 to form the immunomodulatory cytokines IL-27 and IL-35, respectively.  
Infection of EBI3-/- mice with the neuroadapted JHM strain of mouse hepatitis virus (JHMV) resulted in increased mortality that was not associated with impaired ability to control viral replication but enhanced T cell and macrophage infiltration into the CNS.
 IFN-γ secretion from virus-specific CD4+ and CD8+ T cells isolated from infected EBI3-/- mice was augmented while IL-10 expression muted ( vaimentunut)  in comparison to infected WT mice. These data demonstrate a regulatory role for EBI3-associated cytokines in controlling host responses following CNS viral infection.
PMID:
23102608
PMCID:
PMC3534940
DOI:
10.1016/j.jneuroim.2012.10.005
[Indexed for MEDLINE]
Free PMC Article

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