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måndag 9 mars 2020

COVID-19, nsp5 (3264..3569), 306 aminohappoa

    mat_peptide     3264..3569
                     /product="3C-like proteinase"
                     /note="nsp5; main proteinase (Mpro); mediates cleavages
                     downstream of nsp4. 3D structure has been determined (Yang
                     et al., 2003); produced by both pp1a and pp1ab"
FEATURES             Location/Qualifiers
     source          1..306
                     /organism="Severe acute respiratory syndrome coronavirus
                     2"
                     /isolate="SARS-CoV-2/Yunnan-01/human/2020/CHN"
                     /isolation_source="sputum"
                     /host="Homo sapiens"
                     /db_xref="taxon:2697049"
                     /country="China: Yunnan"
                     /collection_date="17-Jan-2020"
     Protein         <1 ..="">306
                     /product="orf1ab polyprotein"
     mat_peptide     1..306
                     /product="3C-like proteinase"
                     /note="nsp5; main proteinase (Mpro); mediates cleavages
                     downstream of nsp4. 3D structure has been determined (Yang
                     et al., 2003); produced by both pp1a and pp1ab"
     CDS             1..4405
                     /gene="orf1a"
                     /coded_by="MT049951.1:266..13483"
                     /note="pp1a"
ORIGIN      
        1 sgfrkmafps gkvegcmvqv tcgtttlngl wlddvvycpr hvictsedml npnyedllir
       61 ksnhnflvqa gnvqlrvigh smqncvlklk vdtanpktpk ykfvriqpgq tfsvlacyng
      121 spsgvyqcam rpnftikgsf lngscgsvgf nidydcvsfc ymhhmelptg vhagtdlegn
      181 fygpfvdrqt aqaagtdtti tvnvlawlya avingdrwfl nrftttlndf nlvamkynye
      241 pltqdhvdil gplsaqtgia vldmcaslke llqngmngrt ilgsallede ftpfdvvrqc
      301 sgvtfq
// 
 
kiinalaisesta Orf1a pp1a peptidistä  
ja suomalaisesta peptidistä Samanlaisilta näyttävät yhdellä läpikäynnillä. 
 
 3264        sgfrkma fpsgkvegcm vqvtcgtttl nglwlddvvy
     3301 cprhvictse dmlnpnyedl lirksnhnfl vqagnvqlrv ighsmqncvl klkvdtanpk
     3361 tpkykfvriq pgqtfsvlac yngspsgvyq camrpnftik gsflngscgs vgfnidydcv
     3421 sfcymhhmel ptgvhagtdl egnfygpfvd rqtaqaagtd ttitvnvlaw lyaavingdr
     3481 wflnrftttl ndfnlvamky nyepltqdhv dilgplsaqt giavldmcas lkellqngmn
     3541 grtilgsall edeftpfdvv rqcsgvtfq
 
3264         sgfrkma fpsgkvegcm vqvtcgtttl nglwlddvvy
     3301 cprhvictse dmlnpnyedl lirksnhnfl vqagnvqlrv ighsmqncvl klkvdtanpk
     3361 tpkykfvriq pgqtfsvlac yngspsgvyq camrpnftik gsflngscgs vgfnidydcv
     3421 sfcymhhmel ptgvhagtdl egnfygpfvd rqtaqaagtd ttitvnvlaw lyaavingdr
     3481 wflnrftttl ndfnlvamky nyepltqdhv dilgplsaqt giavldmcas lkellqngmn
     3541 grtilgsall edeftpfdvv rqcsgvtfq

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