Review
RNA ribose methylation (2′-O-methylation): Occurrence, biosynthesis and biological functions☆
Author links open overlay panelLiliaAyadiaAdelineGalvaninaFlorianPichotbVirginieMarchandbYuriMotorina
Highlights
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- Ribose 2’-O-methylation is very common RNA modification omnipresent in cellular RNAs (rRNAs/tRNAs/mRNAs/sn(sno)RNAs/miRNAs…).
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- Formation of 2’-O-methylated residues is insured by both protein stand-alone enzymes and by C/D-box sno(s)RNP complexes.
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- Ribose methylation in RNA is dynamic and responds to physiological state of the cell.
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- Ribose methylation is important for regulation of RNA stability, mRNA splicing and translation, as well as innate immune response.
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