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onsdag 11 mars 2020

2´O-riboosi-metyylitransferaasin merkitys

 

Review
RNA ribose methylation (2′-O-methylation): Occurrence, biosynthesis and biological functions
https://doi.org/10.1016/j.bbagrm.2018.11.009

Highlights
Ribose 2’-O-methylation is very common RNA modification omnipresent in cellular RNAs (rRNAs/tRNAs/mRNAs/sn(sno)RNAs/miRNAs…).
Formation of 2’-O-methylated residues is insured by both protein stand-alone enzymes and by C/D-box sno(s)RNP complexes.
Ribose methylation in RNA is dynamic and responds to physiological state of the cell.
Ribose methylation is important for regulation of RNA stability, mRNA splicing and translation, as well as innate immune response.

https://www.ebi.ac.uk/interpro/entry/InterPro/IPR013123/

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