2´O-riboosi-metyylitransferaasin merkitys

 

Review

RNA ribose methylation (2′-O-methylation): Occurrence, biosynthesis and biological functions☆

Author links open overlay panelLiliaAyadi^aAdelineGalvanin^aFlorianPichot^bVirginieMarchand^bYuriMotorin^a

https://doi.org/10.1016/j.bbagrm.2018.11.009

Highlights

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Ribose 2’-O-methylation is very common RNA modification omnipresent in cellular RNAs (rRNAs/tRNAs/mRNAs/sn(sno)RNAs/miRNAs…).

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Formation of 2’-O-methylated residues is insured by both protein stand-alone enzymes and by C/D-box sno(s)RNP complexes.

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Ribose methylation in RNA is dynamic and responds to physiological state of the cell.

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Ribose methylation is important for regulation of RNA stability, mRNA splicing and translation, as well as innate immune response.

https://www.ebi.ac.uk/interpro/entry/InterPro/IPR013123/