Leta i den här bloggen

Visar inlägg med etikett EBOV järjestäytyminen. Visa alla inlägg
Visar inlägg med etikett EBOV järjestäytyminen. Visa alla inlägg

fredag 14 november 2014

Ebolaviruksella on moduloivan polyploidian kykyä järjestäytymisessään

Miltähän kehoproteiinijärjestelmältä  EBOV on pihistänyt  tuollaisen  organisatorisen kyvyn?-  aikamme einsteinit selvittävät tätä asiaa parhaillaan.

The Organisation of Ebola Virus Reveals a Capacity for Extensive, Modular Polyploidy
Beniac DR, Melito PL, Devarennes SL, Hiebert SL, Rabb MJ, Lamboo LL, Jones SM, Booth TF - PLoS ONE (2012)


http://openi.nlm.nih.gov/detailedresult.php?img=3256159_pone.0029608.g006&req=4

 pone-0029608-g006: Schematic model of Ebola virus genome packaging.EBOV appears pleomorphic, but an underlying structural organization is maintained. In the model we show the three basic morphological forms of EBOV particles; empty, linked, and continuous
Single genome (G1) virus and multi-genome particles are shown budding from the cell.
 In this model genomes are assembled in the host cell and transported to the surface where the end-to-end apposition that we have observed by cryo-EM in mature virions takes place during (or prior to) budding and envelopment at the plasma membrane. The color-coding is as follows: nucleocapsids, red, yellow and orange helices; nucleocapsid protein, purple spheres; VP40, green ovals, VP24/VP35 bridges, blue oval; GP spikes, red; microtubules, brown.

Schematic model of Ebola virus genome packaging.EBOV appears pleomorphic, but an underlying structural organization is maintained. In the model we show the three basic morphological forms of EBOV particles; empty, linked, and continuous. Single genome (G1) virus and multi-genome particles are shown budding from the cell. In this model genomes are assembled in the host cell and transported to the surface where the end-to-end apposition that we have observed by cryo-EM in mature virions takes place during (or prior to) budding and envelopment at the plasma membrane. The color-coding is as follows: nucleocapsids, red, yellow and orange helices; nucleocapsid protein, purple spheres; VP40, green ovals, VP24/VP35 bridges, blue oval; GP spikes, red; microtubules, brown.