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fredag 20 februari 2026

Valaiseva tuore artikkeli nykyisistä Sars-2-Cov varianteista , erityisesti " Stratuksesta" XFG

 https://pmc.ncbi.nlm.nih.gov/articles/PMC12827822/

. 2026 Jan 10;16(1):8. doi: 10.1007/s44197-025-00510-x

The Emergence and Characterization of SARS-CoV-2 Variant XFG (“Stratus”): Comparative Virological, Epidemiological, and Public-Health Perspectives

 1,  2,  2,  3,4,  2,5,✉
PMCID: PMC12827822  PMID: 41519993

Abstract

Background

SARS-CoV-2 continues to diversify under the selective pressure of population immunity, with recombination increasingly contributing to the emergence of new lineages. The recombinant lineage XFG (“Stratus”), detected in early 2025, has attracted attention because it combines genetic features from distinct Omicron descendants and has expanded across multiple regions.SARS-CoV-2 continues to diversify under the selective pressure of population immunity, with recombination increasingly contributing to the emergence of new lineages. The recombinant lineage XFG (“Stratus”), detected in early 2025, has attracted attention because it combines genetic features from distinct Omicron descendants and has expanded across multiple regions.

Objective

To synthesize the current virological, immunological, epidemiological, and clinical evidence on XFG, and to contextualize its public-health significance through comparison with the closely related Omicron-derived lineages JN.1 and NB.1.8.1.…

Approach

This narrative review integrates available molecular and immune data with surveillance observations and emerging clinical reports, translating technical findings into implications that are relevant for healthcare systems and the people they serve.

Key findings

Across available datasets, XFG shows modest immune escape and a moderate growth advantage, yet there is no signal of increased clinical severity compared with recent Omicron sublineages. Current evidence supports the continued effectiveness of vaccines and antivirals, reinforcing that incremental viral adaptation is compatible with stable clinical outcomes in immunologically experienced populations.

Conclusions

XFG exemplifies ongoing, “quiet” SARS-CoV-2 evolution—more consistent with antigenic fine-tuning than a shift toward greater virulence. For individuals, the practical message remains steady: stay updated with vaccination when eligible and seek timely care when at higher risk. For health systems, sustained genomic surveillance, targeted protection of vulnerable groups, and measured risk communication remain central to resilient coexistence with SARS-CoV-2.

Keywords: SARS-CoV-2 variants, Omicron recombinants, XFG (Stratus), JN.1, NB.1.8.1, Immune escape, Genomic surveillance, Public-health preparedness

Introduction

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Etiketter: ,

WHO antaa viitteellisen taulukon sars-2 cov varianteista tämän vuoden alkukuun epiviikoilta

 

Table 3. Weekly prevalence of SARS-CoV-2 VOIs and VUMs

VariantVariant type21 Dec 202528 Dec 20254 Jan 202611 Jan 202618 Jan 2026
BA.3.2
VUM5.273.963.373.362.17
JN.1VOI7.043.724.274.724.25
KP.3.1.1
VUM2.062.011.320.870.76
LP.8.1
VUM0.530.240.060.250.09
NB.1.8.1
VUM1516.818.120.621.1
XFG
VUM62.265.365.663.161.7

Footnote: Variants presented in this table include the respective descendant lineages, except those individually specified elsewhere in the table.

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GISAID kartalta Sars-2-cov varianttien vaiheesta 20.2.2026

 https://gisaid.org/sars-cov-2-phylogenetics/global/

GISAID kartat näyttävät   varianttipuun  latvojen turkoosinkirkkaita  haaroittumia. 

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Pango kirjain koodien kertaus. yhden ja kahden kirjaimen koodit siihen asti kun niitä on otettu sars-2 varianttien nimitykseen.

   https://www.blogger.com/blog/posts/9185631293657658555 

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    "NC": "B.1.1.529.2.86.1.1.13.1.1.1.1",

    "ND": "B.1.1.529.2.86.1.1.16.1.8.1.1",

    "NE": "B.1.1.529.2.86.1.1.11.1.1.1.6",

    "NF": "B.1.1.529.2.86.1.1.16.5",

    "NG": "B.1.1.529.2.86.1.1.11.1.2.3.9",

    "NH": "B.1.1.529.2.86.1.1.11.1.2.2.1",

    "NJ": "B.1.1.529.2.86.1.1.11.2",

    "NK": "B.1.1.529.2.86.1.1.11.1.2.3.10",

    "NL": "B.1.1.529.2.86.1.1.9.2.1.3.1",

    "NM": "B.1.1.529.2.86.1.1.11.1.2.3.4",

    "NN": "B.1.1.529.2.86.1.1.11.1.2.3.13",

    "NP": "B.1.1.529.2.86.1.1.11.1.3.3.2",

    "NQ": "B.1.1.529.2.86.1.1.11.1.3.3.1",

    "NR": "B.1.1.529.2.86.1.1.11.1.3.1.11",

    "NS": "B.1.1.529.2.86.1.1.16.3",

    "NT": "B.1.1.529.2.86.1.1.16.1.7.1.2",

    "NU": "B.1.1.529.2.86.1.1.55.2",

    "NV": "B.1.1.529.2.86.1.1.11.1.3.2.9",

    "NW": "B.1.1.529.2.86.1.1.11.1.1.1.3.8.1.2",

    "NY": "B.1.1.529.2.86.1.1.11.1.1.1.3.8.1.1",

    "NZ": "B.1.1.529.2.86.1.1.9.2.1.3.4",

    "PA": "B.1.1.529.2.86.1.1.11.1.3.1.1.10.1.1",

    "PB": "B.1.1.529.2.86.1.1.11.1.3.3.8",

    "PC": "B.1.1.529.2.86.1.1.16.1.7.2.1",

    "PD": "B.1.1.529.2.86.1.1.11.1.1.1.3.8.1.4",

    "PE": "B.1.1.529.2.86.1.1.11.1.3.1.1.10.2.1",

    "PF": "B.1.1.529.2.86.1.1.11.1.1.1.3.8.1.6",

    "PG": "B.1.1.529.2.86.1.1.11.1.3.3.5",

    "PH": "B.1.1.529.2.86.1.1.11.1.3.1.1.10.1.6",

    "PJ": "B.1.1.529.2.86.1.1.11.1.3.1.1.10.1.7",

    "PK": "B.1.1.529.2.86.1.1.23.1",

    "PL": "B.1.1.529.2. ''86.1.1.16.1.7.1.10",

    "PM": "B.1.1.529.2.86.1.1.11.1.3.2.6",

    "PN": "XDV.1.7.1",

    "PP": "B.1.1.529.2.86.1.1.11.1.1.1.3.8.1.8",

    "PQ": "XDV.1.5.1.1.8.1",

    "PR": "B.1.1.529.2.86.1.1.11.1.1.1.3.8.1.5",

    "PS": "B.1.1.529.2.86.1.1.49.1.1.1.1.1.1.1",

    "PT": "XEC.4.1.1",

....."PU": "XEC.4.1.3",

    "PV": "B.1.1.529.2.86.1.1.16.1.7.7.1",

    "PW": "B.1.1.529.2.86.1.1.16.1.7.9.2",

    "PY": "B.1.1.529.2.86.1.1.16.1.7.9.1",

    "PZ": "B.1.1.529.2.86.1.1.16.1.7.1.4",

    "QA": "B.1.1.529.2.86.1.1.16.1.7.1.3",

    "QB": "B.1.1.529.2.86.1.1.16.1.7.1.13",

    "QC": "B.1.1.529.2.86.1.1.16.1.7.6.2",

    "QD": "B.1.1.529.2.86.1.1.16.1.7.1.8",

    "QE": "B.1.1.529.2.86.1.1.11.1.1.1.3.8.1.16",

    "QF": "XFG.3.4.1",

    "QG": "XEC.4.1.2",

    "QH": "B.1.1.529.2.86.1.1.11.1.1.1.3.8.1.7",

    "QJ": "B.1.1.529.2.86.1.1.16.1.7.1.6",

    "QK": "XFG.3.1.2",

    "QL": "XDV.1.5.1.1.1.1",

    "QM": "B.1.1.529.2.86.1.1.11.1.1.1.3.8.1.2.1.2.1",

    "QN": "XDV.1.5.1.1.5.1",

    "QP": "B.1.1.529.2.86.1.1.11.1.3.1.1.10.2.2",

    "QQ": "XFG.17.2.1",

    "QR": "B.1.1.529.2.86.1.1.16.1.7.7.2",

    "QS": "XFG.3.4.3",

    "QT": "XFG.3.4.2",

    "QU": "B.1.1.529.2.86.1.1.11.1.1.1.3.8.1.1.3.1.2",

    "QV": "B.1.1.529.2.86.1.1.16.1.7.2.2",

    "QW": "XFG.5.4.1",

    "QY": "XFG.4.1.3",

   "QZ": "XFG.7.1.1",

    "RA": "XFJ.3.1.1",

    "RB": "XFG.23.1.1",

    "RC": "XDV.1.5.1.1.8.1.2.8.1",

    "RD": "B.1.1.529.3.2.1",

    "RE": "B.1.1.529.3.2.2",

    "RF": "B.1.1.529.2.86.1.1.16.1.7.9.1.1.1.1",

    "RG": "B.1.1.529.2.86.1.1.11.1.1.1.3.8.1.2.1.2.2",

    "RH": "XDV.1.5.1.1.8.1.10.1.4",

    "RJ": "XDV.1.5.1.1.8.1.4.6.2",

    "RK": "XDV.1.5.1.1.8.1.17.7.2",

    "RL": "XFG.14.1.2",

    "RM": "XFG.5.2.5",

    "RN": "XFG.3.4.6",

    "RP": "XFG.1.1.1",

    "RQ": "XDV.1.5.1.1.8.1.2.5.2",

    "RR": "XDV.1.5.1.1.8.1.14.3.1",

    "RS": "B.1.1.529.3.2.2.1.1.1",

    "RT": "B.1.1.529.3.2.2.2.2.4",

    "RU": "B.1.1.529.3.2.2.2.2.2",

    "RV": "XFG.23.1.3",

Tähän asti käytetty  kirjainten 2 kombinaatiota nyt . 

.....Alkurekominanttien kombinaationimiä X ja toinen kirjan

    "XA": ["B.1.1.7","B.1.177"],

    "XB": ["B.1.634","B.1.631"],

    "XC": ["AY.29","B.1.1.7"],

    "XD": ["B.1.617.2*","BA.1*"],

    "XE": ["BA.1*","BA.2*"],

    "XF": ["B.1.617.2*","BA.1*"],

    "XG": ["BA.1*","BA.2*"],

    "XH": ["BA.1*","BA.2*"],

    "XJ": ["BA.1*","BA.2*"],

    "XK": ["BA.1*","BA.2*"],

    "XL": ["BA.1*","BA.2*"],

    "XM": ["BA.1.1*","BA.2*"],

    "XN": ["BA.1*","BA.2*"],

    "XP": ["BA.1.1*","BA.2*"],

    "XQ": ["BA.1.1*","BA.2*"],

    "XR": ["BA.1.1*","BA.2*"],

    "XS": ["B.1.617.2*","BA.1.1*"],

    "XT": ["BA.2*","BA.1*"],

    "XU": ["BA.1*","BA.2*"],

    "XV": ["BA.1*","BA.2*"],

    "XW": ["BA.1*","BA.2*"],

    "XY": ["BA.1*","BA.2*"],

    "XZ": ["BA.2*","BA.1*


  https://gisaid.org/sars-cov-2-phylogenetics/global/ 

    ,Sitten tarvitaan rekombinanttien nimeämiseen kolme kirjainta X + 2. Nämä kopsasin Githubista toiseen kohtaan. 

    "XAA": ["BA.1*","BA.2*"],

    "XAB": ["BA.1*","BA.2*"],

Koetan sittenkin koota tähän  kolminumeroiset rekombit  loppupään luetteloa 

"XDD": ["EG.5.1.1","JN.1","EG.5.1.1"],
    "XDE": ["GW.5.1","FL.13.4"],
    "XDF": ["XBB*","EG.5.1.3"],
    "XDG": ["FL.37","EG.5.2.4"],
    "XDH": ["BN.1.2.8","XBB.1.9.1"],
    "XDJ": ["XBB.1.16.6","HK.3.1"],
    "XDK": ["XBB.1.16.11","JN.1.1.1"],
    "XDL": ["EG.5.1.1","XBB*"],
    "XDM": ["XDA","GW.5","XDA"],
    "XDN": ["JN.1.1","JD.1*"],
    "XDP": ["JN.1.4","FL.15"],
    "XDQ": ["BA.2.86.1","FL.15.1.1"],
    "XDR": ["JD.1.1.1","JN.1.1"],
    "XDS": ["EG.5.1.3","JN.3.2.1","EG.5.1.3"],
    "XDT": ["BA.2.86.4","GK.1"],
    "XDU": ["XBB.1.16","BA.2.86.1"],
    "XDV": ["XDE","JN.1","XDE","JN.1"],
    "XDW": ["JN.2","XDA"],
    "XDY": ["LB.1.2.1","KP.3.2"],
    "XDZ": ["JG.3","JN.1.1.10"],
    "XEA": ["JN.1.63.1","EG.5"],
    "XEB": ["FL.15","JN.1.4","FL.15"],
    "XEC": ["KS.1.1","KP.3.3"],
    "XED": ["JN.1.4","LF.1.1.1"],
    "XEE": ["KP.2.3.7", "JN.1"],
    "XEF": ["LB.1.4", "KP.3"],
    "XEG": ["JN.3.2.1","GJ.1.2","JN.3.2.1","GJ.1.2"],
    "XEH": ["KP.1.1.3","KP.3"],
    "XEJ": ["JN.1", "LF.1.1.1"],
    "XEK": ["KP.2.3","XEC"],
    "XEL": ["KS.1.1.2","JN.1"],
    "XEM": ["KS.1","KP.3.3.1"],
    "XEN": ["KP.1.1.6","JN.1.11.1"],
    "XEP": ["KP.3.1.1","NP.2"],
    "XEQ": ["KS.1.1.2","KP.3"],
    "XER": ["KS.2","LF.7"],
    "XES": ["KP.2.3","KP.3.3"],
    "XET": ["KP.1.1.1","KP.3.1.1"],
    "XEU": ["XEK","XEC.8"]
,(Lisään XEU jälkeen tulleet  20.2. 2026. 

    "XEV": ["KP.3.1.1","XEC.18"],

    "XEW": ["KP.3.1.1","XEC.8"],

    "XEY": ["MC.29","XEC"],

    "XEZ": ["MC.6","XEC"],

    "XFA": ["MC.1.1.1","XEC.4.1"],

    "XFB": ["MC.24","XDY.1.1","MC.24"],

    "XFC": ["LP.8.1.1","LF.7","LP.8.1.1"],

    "XFD": ["MC.36.1","XEC"],

    "XFE": ["MC.37","XEC.19"],

    "XFF": ["LB.1.3","MZ.1"],

    "XFG": ["LF.7","LP.8.1.2","LF.7"],

    "XFH": ["LF.7.1.13","XEF","LF.7.1.13"],

    "XFJ": ["LS.2.1.1","LF.7.2","LS.2.1.1","LF.7.2"],

    "XFK": ["KP.3.1.1","XEC.5"],

    "XFL": ["XEU","XEC.18"],

    "XFM": ["LF.7.6.2","LS.2.1.1"],

    "XFN": ["XEC.25.1","LF.7","XEC.25.1"],

    "XFP": ["LS.2.1.1","LF.7","LS.2.1.1"],

    "XFQ": ["LF.7.1.10","XFG.3.1"],

    "XFR": ["LF.7.3","LB.1.11.1"],

    "XFS": ["LF.7.1","LP.8.1.9"],

    "XFT": ["LF.7.7.2","LP.8.1.1"],

    "XFU": ["LF.7.6.2","PG.3.1"],

    "XFV": ["LP.8.1","XFG.3.3.1"],

    "XFW": ["XDY.3","LF.7","XDY.3"],

    "XFY": ["XFG.5.1","NB.1.8.1"],

    "XFZ": ["XFC.3","PG.3.2"],

    "XGA": ["XFJ.4.1","PY.1","XFG.6.2"],

    "XGB": ["NW.1.7","QS.1"],

    "XGC": ["PY.2","XFG.4"],

    "XGD": ["XFJ.4","XFJ.3.1.3"],

    "XGE": ["XFG.2","XFG.14.1"],

    "XGF": ["XFG.3.13","XFG.14.1"],

    "XGG": ["PY.1","XFG.21"],

    "XGH": ["QY.3","PY.1.4","QY.3"],

    "XGJ": ["XFG.10","XFG.17.2.1"],

    "XGK": ["XFG.2.12","XFG.17.2.1"],

    "XGL": ["XFG.3.1.12","XFG.17.2.1"],

    "XGM": ["NY.3.3","LF.7.3","NY.3.3"],

    "XGN": ["XFG.3.5.2","RG.3","XFG.3.5.2"],

    "XGP": ["NY.3.3","XFG.26"],

    "XGQ": ["PP.1.2","XFG.26","PP.1.2"],

    "XGR": ["NW.1.7.4","RN.1"],

    "XGS": ["XFG","PY.1","XFG"],

    "XGT": ["QF.2","PQ.17","QF.2"]

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fredag 23 januari 2026

SARS-2 variantti BA.3.2 ilmenee. VUM. Tällä omicron BA.3 johdannaisella on evaasiokapasiteettia rokotetuissa.. ehkä

 https://data.who.int/dashboards/covid19/variants?n=c

Genetic features
Relative to Index: P9L, R21T, P26L, A67V, H69-, V70-, T95I, I101T, C136-, N137-, D138-, P139-, F140-, L141-, G142-, V143-, Y144-, Y145-, H146-, K147-, F157S, N164K, S172F, K187T, N211-, L212I, A243-, L244-, P251S, I326V, G339Y, A348P, S371F, S373P, S375F, R403K, D405N, R408S, K417N, A435S, N440R, V445A, G446D, L452W, N460K, S477N, T478N, E484K, G496S, Q498R, N501Y , K529N, E554D, E583D, D614G, H625R, N641K, V642G, E654K, H655Y , N679R, P681R, A688D, S704L, N764K, K795T, D796Y , A852K, S939F, Q954H, N969K, P1162R, D1184E

Earliest documented samples
22 November 2025

Date of designation
5 December 2025


    Risk assessment
  • 05 December 2025
    BA.3.2 Initial Risk Evaluation
  • WHO TAG-VE Risk Evaluation for SARS-CoV-2 Variant Under Monitoring: BA.3.2 Executive Summary BA.3.2 has been designated a SARS-CoV-2 Variant Under Monitoring (VUM). Although it demonstrates antigenic drift and reduced neutralization in vitro, currently approved COVID-19 vaccines are expected to continue providing protection against severe disease. There have been reports from Western Australia of elevated BA.3.2 wastewater signals. Recently, BA.3.2 was detected, though still very low-level, in wastewater from some U.S. states. However, BA.3.2 has not shown a sustained growth advantage over any other cocirculating variant, and no data indicate increased severity, hospitalisations, or deaths associated with this variant. Overall, available evidence suggests that BA.3.2 poses low additional public health risk compared with other circulating Omicron descendent lineages.
  • Initial Risk Evaluation of BA.3.2, 5 December 2025 BA.3.2 is a SARS-CoV-2 variant that is a descendent lineage of the Omicron variant BA.3, Figure 1A, differing from BA.3 in the Spike protein by 53 mutations [1], Figure 1B, with the earliest sample collected on 22 November 2024. Phylodynamic analysis estimates the variant to have emerged between December 2023 and July 2024 [2]. BA.3.2 is one of six VUMs tracked by the WHO [3,4]


PubMed haku OMICRON BA.3.2 
2 artikkelia:
 
Antibody responses to SARS-CoV-2 variants LP.8.1, LF.7.1, NB.1.8.1, XFG and BA.3.2 following KP.2 monovalent mRNA vaccination.
Abbad A, Lerman B, Ehrenhaus J, Monahan B, Singh G, Wilson A, Slamanig S, Aracena A, Lyttle N, Nardulli J, Farrugia K, Khalil Z, Gonzalez-Reiche AS, Sordillo EM, Sun W, van Bakel HM, Simon V, Krammer F.medRxiv [Preprint]. 2025 Sep 19:2025.08.24.25333689. doi: 10.1101/2025.08.24.25333689.Update in: mBio. 2026 Jan 14;17(1):e0290125. doi: 10.1128/mbio.02901-25.PMID: 40909860 Free PMC article. Preprint.
We assessed neutralizing antibody responses in 56 adults with varied exposure histories following KP.2 vaccination against emerging variants including LP.8.1, LF.7.1, NB.1.8.1, XFG, and BA.3.2. While KP.2 vaccination enhanced neutralization against homologous …
 
Antibody responses to SARS-CoV-2 variants LP.8.1, LF.7.1, NB.1.8.1, XFG, and BA.3.2 following KP.2 monovalent mRNA vaccination.
Abbad A, Lerman B, Ehrenhaus J, Monahan B, Singh G, Wilson A, Slamanig S, Aracena A, Lyttle N, Nardulli JR, Farrugia K, Khalil Z, Gonzalez-Reiche AS, Sordillo ME, Sun W, van Bakel H, Simon V, Krammer F.mBio. 2026 Jan 14;17(1):e0290125. doi: 10.1128/mbio.02901-25. Epub 2025 Nov 25.PMID: 41288098 Free PMC article.
We assessed neutralizing antibody responses in 56 adults with varied exposure histories following KP.2 vaccination against emerging variants including LP.8.1, LF.7.1, NB.1.8.1, XFG, and BA.3.2. While KP.2 vaccination enhanced neutralization against homologous …

Volume 6, Issue 11101165November 2025Open access

Host cell entry and neutralisation sensitivity of SARS-CoV-2 BA.3.2

a ∙ a,b ∙ a ∙ a ∙ d,f ∙ c,d,e,f ∙ et al. Show more
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