Lintuinfluenssa HPAI H5N1 viruksen HA-peptidin pilkkoutumiskohdan motiivi

 https://pmc.ncbi.nlm.nih.gov/articles/PMC5057330/

. 2015 Oct 15;25(6):406–430. doi: 10.1002/rmv.1846

Molecular pathogenesis of H5 highly pathogenic avian influenza: the role of the haemagglutinin cleavage site motif

Jasmina M Luczo ^1,2, John Stambas ², Peter A Durr ¹, Wojtek P Michalski ¹, John Bingham ^1,✉

PMCID: PMC5057330  PMID: 26467906

HA rakenteen Sveitsin malli  https://swissmodel.expasy.org/repository/uniprot/D9I6N5

 https://swissmodel.expasy.org/repository/uniprot/D9I6N5

Hemagglutinin Q5EP31 (Identical to D9I6N5) UniProtKBInterPro

Toggle Identical (ACE)

Q5EP31 6cfg.(ACE) Q5EP31 6cfg.(ACE) Q5EP31 6cfg.(ACE) Q5EP31 6cfg.(ACE) Q5EP31 6cfg.(ACE) Q5EP31 6cfg.(ACE) Q5EP31 6cfg.(ACE) Q5EP31 6cfg.(ACE) Q5EP31 6cfg.(ACE)

DQICIGYHANNSTEQVDTIMEKNVTVTHAQDILEKKHNGK 56 DQICIGYHANNSTEQVDTIMEKNVTVTHAQDILEKKHNGK 44 LCDLDGVKPLILRDCSVAGWLLGNPMCDEFINVPEWSYIV 96 LCDLDGVKPLILRDCSVAGWLLGNPMCDEFINVPEWSYIV 84 EKANPVNDLCYPGDFNDYEELKHLLSRINHFEKIQIIPKS 136 EKANPVNDLCYPGDFNDYEELKHLLSRINHFEKIQIIPKS 124 SWSSHEASLGVSSACPYQGKSSFFRNVVWLIKKNSTYPTI 176 SWSSHEASLGVSSACPYQGKSSFFRNVVWLIKKNSTYPTI 164 KRSYNNTNQEDLLVLWGIHHPNDAAEQTKLYQNPTTYISV 216 KRSYNNTNQEDLLVLWGIHHPNDAAEQTKLYQNPTTYISV 204 GTSTLNQRLVPRIATRSKVNGQSGRMEFFWTILKPNDAIN 256 GTSTLNQRLVPRIATRSKVNGQSGRMEFFWTILKPNDAIN 244 FESNGNFIAPEYAYKIVKKGDSTIMKSELEYGNCNTKCQT 296 FESNGNFIAPEYAYKIVKKGDSTIMKSELEYGNCNTKCQT 284 PMGAINSSMPFHNIHPLTIGECPKYVKSNRLVLATGLRNS 336 PMGAINSSMPFHNIHPLTIGECPKYVKSNRLVLATGLRNS 324 P 337 P

 

Hemagglutinin A8UDR1 UniProtKBInterPro

Toggle Identical (BDF)

A8UDR1 6cfg.(BDF) A8UDR1 6cfg.(BDF) A8UDR1 6cfg.(BDF) A8UDR1 6cfg.(BDF) A8UDR1 6cfg.(BDF)

GLFGAIAGFIEGGWQGMVDGWYGYHHSNEQGSGYAADKES 382 GLFGAIAGFIEGGWQGMVDGWYGYHHSNEQGSGYAADKES 40 TQKAIDGVTNKVNSIIDKMNTQFEAVGREFNNLERRIENL 422 TQKAIDGVTNKVNSIIDKMNTQFEAVGREFNNLERRIENL 80 NKKMEDGFLDVWTYNAELLVLMENERTLDFHDSNVKNLYD 462 NKKMEDGFLDVWTYNAELLVLMENERTLDFHDSNVKNLYD 120 KVRLQLRDNAKELGNGCFEFYHKCDNECMESVRNGTYDYP 502 KVRLQLRDNAKELGNGCFEFYHKCDNECMESVRNGTYDYP 160 QYSEEARLKREEIS 516 QYSEEARLKREEIS 174