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fredag 14 november 2014

Ebolaviruksella on moduloivan polyploidian kykyä järjestäytymisessään

Miltähän kehoproteiinijärjestelmältä  EBOV on pihistänyt  tuollaisen  organisatorisen kyvyn?-  aikamme einsteinit selvittävät tätä asiaa parhaillaan.

The Organisation of Ebola Virus Reveals a Capacity for Extensive, Modular Polyploidy
Beniac DR, Melito PL, Devarennes SL, Hiebert SL, Rabb MJ, Lamboo LL, Jones SM, Booth TF - PLoS ONE (2012)


http://openi.nlm.nih.gov/detailedresult.php?img=3256159_pone.0029608.g006&req=4

 pone-0029608-g006: Schematic model of Ebola virus genome packaging.EBOV appears pleomorphic, but an underlying structural organization is maintained. In the model we show the three basic morphological forms of EBOV particles; empty, linked, and continuous
Single genome (G1) virus and multi-genome particles are shown budding from the cell.
 In this model genomes are assembled in the host cell and transported to the surface where the end-to-end apposition that we have observed by cryo-EM in mature virions takes place during (or prior to) budding and envelopment at the plasma membrane. The color-coding is as follows: nucleocapsids, red, yellow and orange helices; nucleocapsid protein, purple spheres; VP40, green ovals, VP24/VP35 bridges, blue oval; GP spikes, red; microtubules, brown.

Schematic model of Ebola virus genome packaging.EBOV appears pleomorphic, but an underlying structural organization is maintained. In the model we show the three basic morphological forms of EBOV particles; empty, linked, and continuous. Single genome (G1) virus and multi-genome particles are shown budding from the cell. In this model genomes are assembled in the host cell and transported to the surface where the end-to-end apposition that we have observed by cryo-EM in mature virions takes place during (or prior to) budding and envelopment at the plasma membrane. The color-coding is as follows: nucleocapsids, red, yellow and orange helices; nucleocapsid protein, purple spheres; VP40, green ovals, VP24/VP35 bridges, blue oval; GP spikes, red; microtubules, brown.

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