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måndag 9 mars 2020

COVID-19, nsp16 ( 6799..7096), 298 aminohappoa

 mat_peptide     6799..7096
                     /product="2'-O-ribose methyltransferase"
                     /note="nsp16; 2'-o-MT; produced by pp1ab only"
                     /protein_id="YP_009725311.1"
                     /calculated_mol_wt=33324..
FEATURES             Location/Qualifiers
     source          1..298
                     /organism="Severe acute respiratory syndrome coronavirus
                     2"
                     /isolate="Wuhan-Hu-1"
                     /host="Homo sapiens"
                     /db_xref="taxon:2697049"
                     /country="China"
                     /collection_date="Dec-2019"
     Protein         1..298
                     /product="2'-O-ribose methyltransferase"
                     /note="nsp16; 2'-o-MT; produced by pp1ab only"
                     /calculated_mol_wt=33324
     Precursor       1..298
                     /derived_from="YP_009724389.1:6799..7096"
ORIGIN      
        1 ssqawqpgva mpnlykmqrm llekcdlqny gdsatlpkgi mmnvakytql cqylntltla
       61 vpynmrvihf gagsdkgvap gtavlrqwlp tgtllvdsdl ndfvsdadst ligdcatvht
      121 ankwdliisd mydpktknvt kendskegff tyicgfiqqk lalggsvaik itehswnadl
      181 yklmghfaww tafvtnvnas sseafligcn ylgkpreqid gyvmhanyif wrntnpiqls
      241 syslfdmskf plklrgtavm slkegqindm ilsllskgrl iirennrvvi ssdvlvnn
// 
sars2 Swiss model
YP_009725311.1 (298 residues)2'-O-ribose methyltransferase (nsp16):
        Methyltransferase that mediates
        mRNA cap 2'-O-ribose methylation to the 5'-cap structure of viral
        mRNAs. N7-methyl guanosine cap is a prerequisite for binding of nsp16.
        Therefore plays an essential role in viral mRNAs cap methylation which
        is essential to evade immune system.


        High quality models are available. Hetero-oligomeric complex with nsp10 is
        available in hetero section.
        

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