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söndag 8 mars 2020

COVID-19 .ihmisen SARS CoV nsp3 , orf1ab:sta 2020

  mat_peptide     819..2763
                     /product="nsp3"
                     /note="former nsp1; conserved domains are: N-terminal
                     acidic (Ac), predicted phosphoesterase, papain-like
                     proteinase, Y-domain, transmembrane domain 1 (TM1),
                     adenosine diphosphate-ribose 1''-phosphatase (ADRP);
                     produced by both pp1a and pp1ab"

orf1ab polyprotein [Severe acute respiratory syndrome coronavirus 2]

GenBank: QIA20043.1

LOCUS QIA20043 1945 aa linear VRL 12-FEB-2020 DEFINITION orf1ab polyprotein [Severe acute respiratory syndrome coronavirus 2]. ACCESSION QIA20043
 REGION: 819..2763 VERSION QIA20043.1 DBSOURCE accession MT049951.1 KEYWORDS . SOURCE Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ORGANISM Severe acute respiratory syndrome coronavirus 2 Viruses; Riboviria; Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae; Betacoronavirus; Sarbecovirus.
REFERENCE 1 (residues 1637 to 1945)
 AUTHORS Fu,X., Li,D. and Sun,Y.
 TITLE A novel coronavirus associated with a respiratory disease in Kunming of Yunnan province, China JOURNAL
 Unpublished REFERENCE 2 (residues 1637 to 1945)
 AUTHORS Fu,X., Li,D. and Sun,Y. TITLE Direct Submission JOURNAL Submitted (09-FEB-2020) Yunnan Center for Disease Control Prevention, Institute for Acute Communicable Disease Prevention and Control, No. 158, Dongsi Street, Xishan District., Kunming, Yunnan 650022, China

 FEATURES Location/Qualifiers source 1..1945 /organism="Severe acute respiratory syndrome coronavirus 2" /isolate="SARS-CoV-2/Yunnan-01/human/2020/CHN" /isolation_source="sputum" /host="Homo sapiens" /db_xref="taxon:2697049" /country="China: Yunnan" /collection_date="17-Jan-2020" Protein <1 ..="">1945 /product="orf1ab polyprotein" mat_peptide 1..1945 /product="nsp3" /note="former nsp1; conserved domains are: 
N-terminal acidic (Ac),
 predicted phosphoesterase,
 papain-like proteinase, 
Y-domain, 
transmembrane domain 1 (TM1), 
adenosine diphosphate-ribose 1''-phosphatase (ADRP);
 produced by both pp1a and pp1ab"
  CDS 1..4405 /gene="orf1a" /coded_by="MT049951.1:266..13483" /note="pp1a"

 ORIGIN
  1 aptkvtfgdd tvievqgyks vnitfelder idkvlnekcs aytvelgtev nefacvvada
 61 viktlqpvse lltplgidld ewsmatyylf desgefklas hmycsfyppd edeeegdcee
 121 eefepstqye ygteddyqgk plefgatsaa lqpeeeqeed wldddsqqtv gqqdgsednq
181 tttiqtivev qpqlemeltp vvqtievnsf sgylkltdnv yiknadivee akkvkptvvv
 241 naanvylkhg ggvagalnka tnnamqvesd dyiatngplk vggscvlsgh nlakhclhvv
 301 gpnvnkgedi qllksayenf nqhevllapl lsagifgadp ihslrvcvdt vrtnvylavf
 361 dknlydklvs sflemksekq veqkiaeipk eevkpfites kpsveqrkqd dkkikacvee
 421 vtttleetkf ltenlllyid ingnlhpdsa tlvsdiditf lkkdapyivg dvvqegvlta
 481 vviptkkagg ttemlakalr kvptdnyitt ypgqglngyt veeaktvlkk cksafyilps
 541 iisnekqeil gtvswnlrem lahaeetrkl mpvcvetkai vstiqrkykg ikiqegvvdy
 601 garfyfytsk ttvaslintl ndlnetlvtm plgyvthgln leeaarymrs lkvpatvsvs
 661 spdavtayng yltsssktpe ehfietisla gsykdwsysg qstqlgiefl krgdksvyyt
721 snpttfhldg evitfdnlkt llslrevrti kvfttvdnin lhtqvvdmsm tygqqfgpty
 781 ldgadvtkik phnshegktf yvlpnddtlr veafeyyhtt dpsflgryms alnhtkkwky
841 pqvngltsik wadnncylat alltlqqiel kfnppalqda yyrarageaa nfcalilayc
901 nktvgelgdv retmsylfqh anldsckrvl nvvcktcgqq qttlkgveav mymgtlsyeq
 961 fkkgvqipct cgkqatkylv qqespfvmms appaqyelkh gtftcaseyt gnyqcghykh
  1021 itsketlyci dgalltksse ykgpitdvfy kensytttik pvtykldgvv cteidpkldn
 1081 yykkdnsyft eqpidlvpnq pypnasfdnf kfvcdnikfa ddlnqltgyk kpasrelkvt
 1141 ffpdlngdvv aidykhytps fkkgakllhk pivwhvnnat nkatykpntw circlwstkp
 1201 vetsnsfdvl ksedaqgmdn lacedlkpvs eevvenptiq kdvlecnvkt tevvgdiilk
 1261 pannslkite evghtdlmaa yvdnssltik kpnelsrvlg lktlathgla avnsvpwdti
1321 anyakpflnk vvstttnivt rclnrvctny mpyfftlllq lctftrstns rikasmptti
1381 akntvksvgk fcleasfnyl kspnfsklin iiiwflllsv clgsliysta algvlmsnlg
 1441 mpsyctgyre gylnstnvti atyctgsipc svclsgldsl dtypsletiq itissfkwdl
1501 tafglvaewf layilftrff yvlglaaimq lffsyfavhf isnswlmwli inlvqmapis
 1561 amvrmyiffa sfyyvwksyv hvvdgcnsst cmmcykrnra trvecttivn gvrrsfyvya
 1621 nggkgfcklh nwncvncdtf cagstfisde vardlslqfk rpinptdqss yivdsvtvkn
  1681 gsihlyfdka gqktyerhsl shfvnldnlr anntkgslpi nvivfdgksk ceessaksas
 1741 vyysqlmcqp illldqalvs dvgdsaevav kmfdayvntf sstfnvpmek lktlvataea
1801 elaknvsldn vlstfisaar qgfvdsdvet kdvveclkls hqsdievtgd scnnymltyn
1861 kvenmtprdl gacidcsarh inaqvakshn ialiwnvkdf mslseqlrkq irsaakknnl
1921 pfkltcattr qvvnvvttki alkgg //
 

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