COVID-19, nsp4

https://swissmodel.expasy.org/repository/species/2697049
https://www.ncbi.nlm.nih.gov/protein/1802476808

 YP_009725300.1 (500 residues)Non-structural protein 4 (nsp4): Participates in the assembly of virally-induced cytoplasmic double-membrane vesicles necessary for viral replication.
pubMed  lähteestä nsp4 sekvenssi:

nsp4 [Severe acute respiratory syndrome coronavirus 2]

NCBI Reference Sequence: YP_009725300.1

Identical Proteins FASTA Graphics

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LOCUS       YP_009725300             500 aa            linear   VRL 28-JAN-2020
DEFINITION  nsp4 [Severe acute respiratory syndrome coronavirus 2].
ACCESSION   YP_009725300
VERSION     YP_009725300.1
DBLINK      BioProject: PRJNA485481
DBSOURCE    REFSEQ: accession YP_009724389.1
KEYWORDS    RefSeq.
SOURCE      Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
  ORGANISM  Severe acute respiratory syndrome coronavirus 2
            Viruses; Riboviria; Nidovirales; Cornidovirineae; Coronaviridae;
            Orthocoronavirinae; Betacoronavirus; Sarbecovirus.
REFERENCE   1  (residues 1 to 500)
  AUTHORS   Wu,F., Zhao,S., Yu,B., Chen,Y.-M., Wang,W., Hu,Y., Song,Z.-G.,
            Tao,Z.-W., Tian,J.-H., Pei,Y.-Y., Yuan,M.L., Zhang,Y.-L.,
            Dai,F.-H., Liu,Y., Wang,Q.-M., Zheng,J.-J., Xu,L., Holmes,E.C. and
            Zhang,Y.-Z.
  TITLE     A novel coronavirus associated with a respiratory disease in Wuhan
            of Hubei province, China
  JOURNAL   Unpublished
REFERENCE   2  (residues 1 to 500)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (17-JAN-2020) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   3  (residues 1 to 500)
  AUTHORS   Wu,F., Zhao,S., Yu,B., Chen,Y.-M., Wang,W., Hu,Y., Song,Z.-G.,
            Tao,Z.-W., Tian,J.-H., Pei,Y.-Y., Yuan,M.L., Zhang,Y.-L.,
            Dai,F.-H., Liu,Y., Wang,Q.-M., Zheng,J.-J., Xu,L., Holmes,E.C. and
            Zhang,Y.-Z.
  TITLE     Direct Submission
  JOURNAL   Submitted (05-JAN-2020) Shanghai Public Health Clinical Center &
            School of Public Health, Fudan University, Shanghai, China
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence is identical to
            YP_009724389:2764-3263.
            Annotation was added using homology to SARSr-CoV NC_004718.3. If
            you have questions or suggestions,--Find all other Wuhan seafood market pneumonia virus
            (2019-nCov) sequences at
            https://www.ncbi.nlm.nih.gov/genbank/2019-ncov-seqs/
            
            ##Assembly-Data-START##
            Assembly Method       :: Megahit v. V1.1.3
            Sequencing Technology :: Illumina
            ##Assembly-Data-END##
            Method: conceptual translation.
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Severe acute respiratory syndrome coronavirus
                     2"
                     /isolate="Wuhan-Hu-1"
                     /host="Homo sapiens"
                     /db_xref="taxon:2697049"
                     /country="China"
                     /collection_date="Dec-2019"
     Protein         1..500
                     /product="nsp4"
                     /note="contains transmembrane domain 2 (TM2); produced by
                     both pp1a and pp1ab"
                     /calculated_mol_wt=56184
     Precursor       1..500
                     /derived_from="YP_009724389.1:2764..3263"
ORIGIN      
        1 kivnnwlkql ikvtlvflfv aaifylitpv HvmskHtdfs seiigykaid ggvtrdiast
       61 dtCfankHad fdtwfsqrgg sytndkacpl iaavitrevg fvvpglpgti lrttngdflH
      121 flprvfsavg niCytpskli eytdfatsac vlaaeCtifk dasgkpvpyc ydtnvlegsv
      181 ayeslrpdtr yvlmdgsiiq fpntylegsv rvvttfdsey CrHgtcerse agvcvstsgr
      241 wvlnndyyrs lpgvfCgvda vnlltnmftp liqpigaldi sasivaggiv aivvtclayy
      301 fmrfrrafge ysHvvafntl lflmsftvlc ltpvysflpg vysviylylt fyltndvsfl
      361 aHiqwmvmft plvpfwitia yiiCistkHf ywffsnylkr rvvfngvsfs tfeeaalCtf
      421 llnkemylkl rsdvllpltq ynrylalynk ykyfsgamdt tsyreaaCCH lakalndfsn
      481 sgsdvlyqpp qtsitsavlq
//

High quality models are available for the C-terminus which we predict to be a homo-dimer.



VERTAA:
Allaoleva tieto nsp4 domeenista on SARS-CoV viruksesta 1
region 3146..3238 Corona_Nsp4-C
Nsp4 is a membrane spanniNg protein which is thought to anchor the viral replication transcription complex (RTC) to modified endoplasmiC reticulum membranes. this predominantly alpha helical domain may be involved in protein -protein interaction.