Rifampisiini on sen näköinen kuin siinänolisi siällä INH:n kaltainen hahmo. K saataisi toimia.
atsotaan miten se toimisi antibioootina vaikka koronavirukslle?
MUTTA mitä löytyykää. ADP-riboosiiin vaikuttaa mm geeni: ADPr-transferaasi onkin antibioottiresitnssigeeni vallan.
Sci Rep. 2018 Aug 14;8(1):12143. doi: 10.1038/s41598-018-30547-x.
Integrative metagenomic and biochemical studies on rifamycin ADP-ribosyltransferases discovered in the sediment microbiome.
Antibiotic
resistance is a serious and growing threat to human health. The
environmental microbiome is a rich reservoir of resistomes, offering
opportunities to discover new antibiotic resistance genes. Here we
demonstrate an integrative approach of utilizing gene sequence and
protein structural information to characterize unidentified genes that
are responsible for the resistance to the action of rifamycin antibiotic
rifampin, a
first-line antimicrobial agent to treat tuberculosis. Biochemical
characterization of four environmental metagenomic proteins indicates
that they are adenosine diphosphate
(ADP)-ribosyltransferases and effective in the development of
resistance to FDA-approved rifamycins. Our analysis suggests that even a
single residue with low sequence conservation plays an important role
in regulating the degrees of antibiotic resistance. In addition to
advancing our understanding of antibiotic resistomes, this work
demonstrates the importance of an integrative approach to discover new
metagenomic genes and decipher their biochemical functions.
- PMID:
- 30108275
- PMCID:
- PMC6092378
- DOI:
- 10.1038/s41598-018-30547-x
- [Indexed for MEDLINE]
Inga kommentarer:
Skicka en kommentar