IFITM 1 (11p15.5)

https://www.ncbi.nlm.nih.gov/gene/8519

Official Symbol

IFITM1

Official Full Name

interferon induced transmembrane protein 1provided by HGNC

Also known as

9-27; CD225; IFI17; LEU13; DSPA2a

Expression

Ubiquitous expression in spleen (RPKM 191.9), endometrium (RPKM 153.8) and 24 other tissues See more

Orthologs

Preferred Names

interferon-induced transmembrane protein 1

Names

dispanin subfamily A member 2a

interferon-induced protein 17

interferon-inducible protein 9-27

leu-13 antigen

 Strucutre: 1-125 aminoacids.

TM 87..107. 

https://www.ncbi.nlm.nih.gov/protein/NP_003632.3

 

1. Inhibiting of Proliferation, Migration, and Invasion in Lung Cancer Induced by Silencing Interferon-Induced Transmembrane Protein 1 (IFITM1). Yan J, et al. Biomed Res Int, 2019. PMID 31205947, Free PMC Article
2. Prognostic significance of IFITM1 expression and correlation with microvessel density and epithelial-mesenchymal transition signature in lung adenocarcinoma. Koh YW, et al. Pathol Res Pract, 2019 Jul. PMID 31079850
3. Interferon-induced transmembrane protein 1-mediated EGFR/SOX2 signaling axis is essential for progression of non-small cell lung cancer. Yang YG, et al. Int J Cancer, 2019 Apr 15. PMID 30318841, Free PMC Article
4. IFITM1 expression is crucial to gammaherpesvirus infection, in vivo. Hussein HAM, et al. Sci Rep, 2018 Sep 20. PMID 30237526, Free PMC Article
5. Combination of IFITM1 knockdown and radiotherapy inhibits the growth of oral cancer. Yang J, et al. Cancer Sci, 2018 Oct. PMID 29770536, Free PMC Article

 

1. In lung adenocarcinoma, IFITM1 was an independent prognostic factor for overall survival. Furthermore, high IFITM1 expression was significantly correlated with decreased overall survival rates in each pTNM stage.
2. study revealed the role of IFITM1 as a tumor promoter during lung cancer development and the possible molecular mechanism.
3. These studies identify a novel role for IFITM1, 2, and 3 in inhibiting HIV replication at the level of translation.
4. Silencing IFITM1 expression using siRNA specifically lowered gammaherpesvirus infection of cells at a post binding stage of entry.
5. These results demonstrate that constitutive upregulation of PITX2/IFITM1 cascade is an intrinsic adaptive mechanism during the pathogenesis of letrozole-resistance, and modulation of PITX2/IFITM1 level using different genetic and pharmacological means would thus have a novel therapeutic potential against letrozole resistance in BCa.
6. Using non-small cell lung cancer (NSCLC) cell lines and patient-derived samples, study shows that IFITM1 is essentially required for the progression of NSCLC. IFITM1 depletion resulted in a significant reduction in sphere formation, migration, and invasion of NSCLC cells in vitro. High level of IFITM1 expression is associated with a poor overall survival rate in adenocarcinoma but not in squamous cell carcinoma.
7. overexpression of IFITM1, 2 and 3 suppressed entry of CXCR4 and CCR5 tropic viruses; entry of transmitted founder HIV-1 in U87 cells is more sensitive to inhibition by IFITM2 and IFITM3 than by IFITM1
8. High IFITM1 expression is associated with lymph node metastasis and invasion in Gallbladder Adenocarcinomas
9. Strong ifitm1 Expression in CD4 T Cells in HIV Controllers Is Correlated With Immune Activation
10. Using a multi-group heat map from GSE9716 analysis of the GEO database, IFITM1 was determined to be a relevant radioresistance gene. Inhibition of IFITM1 in combination with radiotherapy could, indeed, inhibit oral neoplasm cells.