Talteen nsp3 interaktioista asiaa.Mitä Swiss model ilmaisee nsp3 :sta, joka on oikea "maagor missaviv" ihmisen soluvaltakunnan järjestyksessä.

Käyttämässäni interaktiolistasa ei ollut nsp3 interaktioita nähdäkseni, joten  Swiss model tiedot. onhan nsp3 tärkeä, koska juuri se  vaikuttaa alkupilkkoutumiset  replikaasissa ja  senjälkeen sitten nsp5 pilkkoo 10 muuta ja virus ponnahtaa  replikaatioon.

Papain-like proteinase (PL-PRO):

• Responsible for the cleavages located at the N-terminus of the replicase polyprotein.
•  In addition, PL-PRO possesses a deubiquitinating/deISGylating activity and processes both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains from cellular substrates.
•  Participates together with nsp4 in the assembly of virally induced cytoplasmic double-membrane vesicles necessary for viral replication.
•  Antagonizes innate immune induction of type I interferon by blocking the phosphorylation, dimerization and subsequent nuclear translocation of host IRF3.
•  Prevents also host NF-kappa-B signaling. 

Partial coverage by experimental structures (PDB:

 6vxs,
Crystal Structure of ADP ribose phosphatase of NSP3 from SARS CoV-2

• DOI: 10.2210/pdb6VXS/pdb 
  Classification: VIRAL PROTEIN

 6w02,
Crystal Structure of ADP ribose phosphatase of NSP3 from SARS CoV-2 in the complex with ADP ribose

• DOI: 10.2210/pdb6W02/pdb 
• Classification: VIRAL PROTEIN

 6w6y,Crystal Structure of ADP ribose phosphatase of NSP3 from SARS CoV-2 in complex with AMP

• DOI: 10.2210/pdb6W6Y/pdb
• Classification: VIRAL PROTEIN, HYDROLASE

 6w9c,
The crystal structure of papain-like protease of SARS CoV-2

• DOI: 10.2210/pdb6W9C/pdb 
  Classification: HYDROLASE

 6wcf,
Crystal Structure of ADP ribose phosphatase of NSP3 from SARS-CoV-2 in complex with MES

• DOI: 10.2210/pdb6WCF/pdb
• Classification: HYDROLASE

 6wen,
Crystal Structure of ADP ribose phosphatase of NSP3 from SARS-CoV-2 in the apo form

• DOI: 10.2210/pdb6WEN/pdb
• Classification: HYDROLASE

6wey,
High-resolution structure of the SARS-CoV-2 NSP3 Macro X domain

• DOI: 10.2210/pdb6WEY/pdb 
•  Classification: VIRAL PROTEIN

 6woj,
Structure of the SARS-CoV-2 macrodomain (NSP3) in complex with ADP-ribose

• DOI: 10.2210/pdb6WOJ/pdb
• Classification: VIRAL PROTEIN

6wrh,
The crystal structure of Papain-Like Protease of SARS CoV-2 , C111S mutant

• DOI: 10.2210/pdb6WRH/pdb 
• Classification: HYDROLASE

6ywk,
Crystal structure of SARS-CoV-2 (Covid-19) NSP3 macrodomain in complex with HEPES

• DOI: 10.2210/pdb6YWK/pdb
• Classification: VIRAL PROTEIN

 6ywl,
Crystal structure of SARS-CoV-2 (Covid-19) NSP3 macrodomain in complex with ADP-ribose

• DOI: 10.2210/pdb6YWL/pdb 
• Classification: VIRAL PROTEIN

 6ywm
Crystal structure of SARS-CoV-2 (Covid-19) NSP3 macrodomain in complex with MES

• DOI: 10.2210/pdb6YWM/pdb 
  Classification: VIRAL PROTEIN

 and high quality models are available.