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fredag 15 maj 2020

SARS-2 CoV nsp11 interaktioproteiiini

TBCA, (5q14.1). Tubulin-specific chaperone A.

https://www.genecards.org/cgi-bin/carddisp.pl?gene=TBCA&keywords=TBCA
The product of this gene is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state. This gene encodes chaperonin cofactor A. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

 https://iiif.elifesciences.org/lax:08811%2Felife-08811-fig1-v2.tif/full/1500,/0/default.jpg


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