Pharmacol Res. 2020 Apr 26:104827. doi: 10.1016/j.phrs.2020.104827. [Epub ahead of print]
Tetrahydrobiopterin in energy metabolism and metabolic diseases.
Tetrahydrobiopterin (BH4)
is an endogenous cofactor for various enzymatic conversions of
essential biomolecules including nitric oxide, tyrosine, dopamine,
serotonin and phenylalanine. Depending on the physiological functions of
these molecules, BH4 plays multiple roles in the cardiovascular, immune, nervous and endocrine systems. A deficiency of BH4
or an imbalance of the redox state of biopterin has been implicated in
various cardiovascular and metabolic diseases. Therefore,
supplementation with BH4
is considered as a therapeutic option for these diseases. In addition
to the classical nitric oxide synthase (NOS)-dependent role of BH4, recent studies proposed novel NOS-independent roles of BH4 in health and disease conditions. This article reviews the updated role of BH4 in mitochondrial regulation, energy metabolism and cardiovascular and metabolic diseases.
Copyright © 2020. Published by Elsevier Ltd. KEYWORDS:
Tetrahydrobiopterin; cardiovascular diseases; energy metabolism; mitochondria
- PMID:
- 32348841
- DOI:
- 10.1016/j.phrs.2020.104827
Inga kommentarer:
Skicka en kommentar