DROSHA (5p13.3) , 1374 aminohappoa. Ribonukleaasi 3. , ZnF-proteiini.

https://www.genecards.org/cgi-bin/carddisp.pl?gene=DROSHA&keywords=DROSHA
Drosha geeni( 5p13.3).
 Drosha esiintyy heterotrimeerinä kahden DGCR8  proteiinin kanssa  jolloin muodostuu pri-miRNAprosessori. - Drosha rakenteessa on kaksi  sinkkisormea: ZnF1 ja ZnF2.   https://www.sciencedirect.com/science/article/pii/S0092867415016438

Drosha tekee interaktion SP1 ja SNIP1 kanssa. Muita DROSHA interaktioita: SRRT/ARS2 ja CPSF3 ja ISY1
Protein attributes for DROSHA Gene

Size:

1374 amino acids

Molecular mass:

159316 Da

Cofactor:

Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035;

Quaternary structure:

• Component of the microprocessor complex, or pri-miRNA processing protein complex, which is composed of DROSHA and DGCR8 (PubMed:15589161, PubMed:15574589, PubMed:15531877, PubMed:16751099, PubMed:26027739, PubMed:26748718). The microprocessor complex is a heterotrimer; each of the two DROSHA RNase III domains binds one DGCR8 (via C-terminal region) (PubMed:26027739, PubMed:26748718). Interacts with SP1 and SNIP1 (PubMed:10976766, PubMed:18632581). Interacts with SRRT/ARS2 (By similarity). Interacts with CPSF3 and ISY1; this interaction is in an RNA dependent manner (By similarity).

HUOM: Sars2 N-proteiini tekee interaktion SNIP1- proteiinin  kanssa, joka on  SMAD- nuklear interaktion tekevä proteiini 1.