SARS-2 ORF6 proteiini-interaktioprofiilista Swiss model

https://covid-19.uniprot.org/uniprotkb/P0DTC6

Function

Disrupts cell nuclear import complex formation by tethering karyopherin alpha 2 and karyopherin beta 1 to the membrane. Retention of import factors at the ER/Golgi membrane leads to a loss of transport into the nucleus. Thereby prevents STAT1 nuclear translocation in response to interferon signaling, thus blocking the expression of interferon stimulated genes (ISGs) that display multiple antiviral activities

Interaction

subunit

Interacts with host KPNA2. May interact with nsp8

Protein-protein interaction databases

IntAct

• P0DTC6

3 interactors

	1	orf6_wcpv	protein	3	EBI-25475897		EBI-25475897	Protein 6 (Sars-2)
	2	nup98_human	protein	1	EBI-295727		EBI-295727	Nuclear pore complex protein Nup98-Nup96
	3	mtch1_human	protein	1	EBI-297455		EBI-297455	Mitochondrial carrier homolog 1
	4	rae1l_human	protein	1	EBI-724495		EBI-724495	mRNA export factor