Interferoni Lambda 1-4 ja niiden heterodimeerinen reseptorikompleksi

https://www.frontiersin.org/articles/10.3389/fimmu.2017.00119/full
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Review ARTICLE

Front. Immunol., 28 February 2017 | https://doi.org/10.3389/fimmu.2017.00119

Interferon Lambda: Modulating Immunity in Infectious Diseases

Mohammedyaseen Syedbasha¹ and Adrian Egli^1,2*

• ¹Applied Microbiology Research, Department of Biomedicine, University of Basel, Basel, Switzerland
• ²Clinical Microbiology, University Hospital Basel, Basel, Switzerland

Figure 1. Type III IFN signaling pathway. Viral infection is sensed by pattern recognition receptors (PRRs), which induce IFN-λ production via various signaling pathways. IFN-λs bind to the heterodimeric IFN-λ receptor (IFNLR), which consists of IL28RA and IL10RB subunits. Upon binding, a JAK–STAT signaling cascade induces hundreds of IFN-stimulated genes (ISGs). RLR, RIG-1-like receptor; TLR, toll-like receptors; NF-κB, nuclear factor kappa-light-chain-enhancer of activated B cells; IL28RA, interleukin 28 receptor alpha; IL10RB, interleukin 10 receptor beta; JAK1, Janus Kinase 1; TYK2, tyrosine kinase 2; STAT, signal transducer and activator of transcription; IRF, interferon regulatory factor; ISRE, interferon-stimulated response element; MX1, interferon-induced GTP-binding protein Mx1; OAS1, 2′-5′-oligoadenylate synthetase.