https://www.genecards.org/cgi-bin/carddisp.pl?gene=FBN1&keywords=FBN-1 This gene encodes a member of the fibrillin family of proteins. The encoded preproprotein is proteolytically processed to generate two proteins including the extracellular matrix component fibrillin-1 and the protein hormone asprosin. Fibrillin-1 is an extracellular matrix glycoprotein that serves as a structural component of calcium-binding microfibrils. These microfibrils provide force-bearing structural support in elastic and nonelastic connective tissue throughout the body. Asprosin, secreted by white adipose tissue, has been shown to regulate glucose homeostasis.
https://www.genecards.org/Search/Keyword?queryString=NUP88
The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins, a family of 50 to 100 proteins, are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene belongs to the nucleoporin family and is associated with the oncogenic nucleoporin CAN/Nup214 in a dynamic subcomplex. This protein is also overexpressed in a large number of malignant neoplasms and precancerous dysplasia
https://www.genecards.org/cgi-bin/carddisp.pl?gene=NUP62&keywords=NUP62
The protein encoded by this gene is a member of the FG-repeat containing nucleoporins and is localized to the nuclear pore central plug. This protein associates with the importin alpha/beta complex which is involved in the import of proteins containing nuclear localization signals. Essential component of the nuclear pore complex. The N-terminal is probably involved in nucleocytoplasmic transport. The C-terminal is involved in protein-protein interaction probably via coiled-coil formation, promotes its association with centrosomes and may function in anchorage of p62 to the pore complex, . Plays a role in mitotic cell cycle progression by regulating centrosome segregation, centriole maturation and spindle orientation . It might be involved in protein recruitment to the centrosome after nuclear breakdown .NUP62_HUMAN,P37198
https://www.genecards.org/cgi-bin/carddisp.pl?gene=NUP58&keywords=NUP58
This gene encodes a member of the nucleoporin family. The protein is localized to the nuclear rim and is a component of the nuclear pore complex (NPC),a complex required for the trafficking across the nuclear membrane. All molecules entering or leaving the nucleus either diffuse through or are actively transported by the NPC.
https://www.genecards.org/cgi-bin/carddisp.pl?gene=EIF4H&keywords=EIF4H
Stimulates the RNA helicase activity of EIF4A in the translation initiation complex. Binds weakly mRNA. https://academic.oup.com/nar/article/40/13/6199/1018198.
https://encrypted-tbn0.gstatic.com/images?q=tbn%3AANd9GcSrVZeP226KzF7gJ2m34dSFZfz1tFHBfrU04-9JavlNbHV6vjcV&usqp=CAU
https://www.genecards.org/cgi-bin/carddisp.pl?gene=SPART&keywords=SPART.
This gene encodes a protein containing a MIT (Microtubule Interacting and Trafficking molecule) domain, and is implicated in regulating endosomal trafficking and mitochondria function. The protein localizes to mitochondria and partially co-localizes with microtubules. Stimulation with epidermal growth factor (EGF) results in protein translocation to the plasma membrane, and the protein functions in the degradation and intracellular trafficking of EGF receptor. Quaternary structure: Interacts with ITCH and WWP1 (PubMed:19580544). Interacts (via MIT domain) with IST1; leading to the recruitment of SPART to midbodies (PubMed:20719964).
https://media.springernature.com/original/springer-static/image/art%3A10.1186%2F1741-7007-8-94/MediaObjects/12915_2010_Article_390_Fig1_HTML.jpg
https://www.genecards.org/cgi-bin/carddisp.pl?gene=NUP214&keywords=NUP214.
This gene is a member of the FG-repeat-containing nucleoporins. The protein encoded by this gene is localized to the cytoplasmic face of the nuclear pore complex where it is required for proper cell cycle progression and nucleocytoplasmic transport. The 3' portion of this gene forms a fusion gene with the DEK gene on chromosome 6 in a t(6,9) translocation associated with acute myeloid leukemia and myelodysplastic syndrome. Interacts with human herpes virus 1 (HHV-1) protein UL25; this interaction might be essential to the capsid docking onto the host nuclear pore.
https://www.genecards.org/cgi-bin/carddisp.pl?gene=FBN2&keywords=FBN2
The protein encoded by this gene is a component of connective tissue microfibrils and may be involved in elastic fiber assembly. : Fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. Fibrillin-2-containing microfibrils regulate the early process of elastic fiber assembly. Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively. Quaternary structure: Interacts with BMP2, BMP4, BMP7, BMP10 and GDF5 (PubMed:18339631). Interacts with MFAP2 and MFAP5 (PubMed:15131124). Interacts with ADAMTSL5 (PubMed:23010571). Interacts with MFAP4 (PubMed:26601954).
https://www.genecards.org/Search/Keyword?queryString=DCAF7
This gene encodes a protein with multiple WD40 repeats which facilitate protein-protein interactions and thereby enable the assembly of multiprotein complexes. This protein has been shown to function as a scaffold protein for protein complexes involved in kinase signaling. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex.
https://www.genecards.org/cgi-bin/carddisp.pl?gene=FBLN5&keywords=FBLN5
Essential for elastic fiber formation, is involved in the assembly of continuous elastin (ELN) polymer and promotes the interaction of microfibrils and ELN (PubMed:18185537). Stabilizes and organizes elastic fibers in the skin, lung and vasculature (By similarity). Promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. Vascular ligand for integrin receptors which may play a role in vascular development and remodeling (PubMed:10428823). May act as an adapter that mediates the interaction between FBN1 and ELN (PubMed:17255108). FBLN5_HUMAN,Q9UBX5
(11) GTF2F2,(13q14.12-q14.13), General transcription factor IIF subunit 2.
https://www.genecards.org/cgi-bin/carddisp.pl?gene=GTF2F2&keywords=GTF2F2.
TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. This subunit shows ATP-dependent DNA-helicase activity. Quaternary structure: Heterodimer of an alpha and a beta subunit.
(12) NUP54,(4q21.1), Nucleoporinp54.
https://www.genecards.org/cgi-bin/carddisp.pl?gene=NUP54&keywords=NUP54
The nuclear envelope creates distinct nuclear and cytoplasmic compartments in eukaryotic cells. It consists of two concentric membranes perforated by nuclear pores, large protein complexes that form aqueous channels to regulate the flow of macromolecules between the nucleus and the cytoplasm. These complexes are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. This gene encodes a member of the phe-gly (FG) repeat-containing nucleoporin subset. Quaternary structure:Component of the p62 complex, a complex composed of NUP62, NUP54, and the isoform p58 and isoform p45 of NUP58. Interacts with NUTF2.
(13) MIB1, (18q11.2), E3 ubiquitin-protein ligase MIB1. ZZZ6, ZZANK2.
https://www.genecards.org/cgi-bin/carddisp.pl?gene=MIB1&keywords=MIB1
This gene encodes a protein containing multiple ankyrin repeats and RING finger domains that functions as an E3 ubiquitin ligase. It mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis (By similarity). Involved in ubiquitination of centriolar satellite CEP131, CEP290 and PCM1 proteins and hence inhibits primary cilium formation in proliferating cells. Mediates 'Lys-63'-linked polyubiquitination of TBK1, which probably participates in kinase activation. MIB1_HUMAN,Q86YT6.
(*Zinc fingers ZZ-type, ZZ-tyyppinen sinkkisormiperhe ( ZZZ - perhe) omaa 18 jäsentä ja niistä on transkriptiotekijöitä 3).
(14) NEK9, (14q24.3), Serine/threonine-protein kinase Nek9
https://www.genecards.org/cgi-bin/carddisp.pl?gene=NEK9&keywords=NEK9
NIMA (Never In Mitosis Gene A)- Related Kinase 9.
This gene encodes a member of the NimA (never in mitosis A) family of serine/threonine protein kinases. The encoded protein is activated in mitosis and, in turn, activates other family members during mitosis. This protein also mediates cellular processes that are essential for interphase progression. Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation. Phosphorylates different histones, myelin basic protein, beta-casein, and BICD2. Phosphorylates histone H3 on serine and threonine residues and beta-casein on serine residues. Important for G1/S transition and S phase progression. Phosphorylates NEK6 and NEK7 and stimulates their activity by releasing the autoinhibitory functions of Tyr-108 and Tyr-97 respectively. NEK9_HUMAN,Q8TD19.
(15) ZNF503 (10q22.2) , Zinc finger protein 503.
May function as a transcriptional repressor. C2H2-tyyppinen sinkkisormiproteiini 503.
( *Zinc fingers C2H2-type ( tunnus: ZNF) on sinkkisormi (Zinc fingers)-perheitten ( yli 40 perhettä) joukossa runsaimmin jäseniä omaava. Siinä on ainakin 720 geeniä ja transcriptiofaktoreita niissä on ainakin 372).
(16) MAT2B (5q34). Methionine adenosyltransferase 2 subunit beta
https://www.genecards.org/cgi-bin/carddisp.pl?gene=MAT2B&keywords=MAT2B
The protein encoded by this gene belongs to the methionine adenosyltransferase (MAT) family. MAT catalyzes the biosynthesis of S-adenosylmethionine from methionine and ATP. This protein is the regulatory beta subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine (SAM) from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine.Can bind NADP (in vitro). MAT2B_HUMAN,Q9NZL9
* https://www.researchgate.net/figure/Methionine-adenosyltransferase-nomenclature-The-scheme-summarizes-the-nomenclature-used_fig2_305472221
(14.5. 2020 muistiin kommentti SARS-2 viruksen nsp9 - proteiinin interaktiogeeneistä. Moni muukin virus näyttää hyödyntävän näitä samoja yllämainittuja interaktioproteiineja. nsp9 vaikuttaa olevan SARS-2 viruksen eräänlainen resurssien alihankkija ja tavarankuljetuslogistiikasta huolehtija. Sanotaan, että RNA-virusmaailmassa SARS-2 nsp9 on ainutlaatuinen. Se on 113 aminohapon peptidi. Se osallistuu replikaatiokompleksiin toimien siinä ss RNA:ta sitovana.
Mitä SWISS model sanoo sen funktiosta:
Non-structural protein 9 (nsp9): May participate in viral replication by acting as a ssRNA-binding protein.
Experimental structures (PDB: 6w4b, 6w9q) and high quality models are available which are predicted to be homo-dimers.
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