SARS-2 nsp1
Vahva interaktiokandidaatti:
(5) POLA1 (Xp22.11-p21.3)
https://www.ncbi.nlm.nih.gov/gene/5422
( DNApolymeraasi alfa1 katalyyttinen alayksikkö)
DNA polymerase alpha 1, catalytic subunit
Also known as NSX; POLA; p180; VEODS
Summary. This gene encodes the catalytic subunit of DNA polymerase, which together with a regulatory and two primase subunits, forms the DNA polymerase alpha complex. The catalytic subunit plays an essential role in the initiation of DNA replication. [provided by RefSeq, Mar 2010] Expression Ubiquitous expression in lymph node (RPKM 2.6), bone marrow (RPKM 2.2) and 25 other tissues
(7) PRIM2 (6p11.2)
(DNA primaasin alayksikkö 2)
https://www.ncbi.nlm.nih.gov/gene/5558
DNA primase subunit 2. Also known as p58; PRIM2A
Summary. This gene encodes the 58 kilodalton subunit of DNA primase, an enzyme that plays a key role in the replication of DNA. The encoded protein forms a heterodimer with a 49 kilodalton subunit. This heterodimer functions as a DNA-directed RNA polymerase to synthesize small RNA primers that are used to create Okazaki fragments on the lagging strand of the DNA. Alternative splicing of this gene results in multiple transcript variants. This gene has a related pseudogene, which is also present on chromosome 6. [provided by RefSeq, Apr 2014 Expression Broad expression in prostate (RPKM 6.3), lymph node (RPKM 1.3) and 21 other tissues.
Interaktio ei ole vahvaa:
(62) PRIM1, (12q13.3)
DNA primase subunit 1, (DNAprimaasin alayksikkkö 1)
https://www.ncbi.nlm.nih.gov/gene/5557
DNA primase subunit 1. Also known as p49.
Summary. The replication of DNA in eukaryotic cells is carried out by a complex chromosomal replication apparatus, in which DNA polymerase alpha and primase are two key enzymatic components. Primase, which is a heterodimer of a small subunit and a large subunit, synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication. The protein encoded by this gene is the small, 49 kDa primase subunit. [provided by RefSeq, Jul 2008]Expression Broad expression in bone marrow (RPKM 10.3), testis (RPKM 9.4) and 25 other tissues.
(105) COLGALT1 (19p13.11)
(kollageeni beta, (1-O) galactosyylitransferaasi 1)
https://www.ncbi.nlm.nih.gov/gene/79709
collagen beta(1-O)galactosyltransferase 1.
Also known as BSVD3; GLT25D1; ColGalT 1
Summary. The protein encoded by this gene is one of two enzymes that transfers galactose moieties to hydroxylysine residues of collagen and mannose binding lectin. This gene is constitutively expressed and encodes a soluble protein that localizes to the endoplasmic reticulum. [provided by RefSeq, Dec 2015] Expression Ubiquitous expression in placenta (RPKM 27.5), appendix (RPKM 22.9) and 25 other tissues
Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of Neisseria gonorrhoeae and Lic2A of Haemophilus influenzae. M. catarrhalis Lgt2 catalyzes the addition of galactose (Gal) to the growing chain of LOS on the cell surface. N. gonorrhoeae LgtB and LgtE link Gal-beta(1,4) to GlcNAc (N-acetylglucosamine) and Glc (glucose), respectively. The genes encoding LgtB and LgtE are two genes of a five gene locus involved in the synthesis of gonococcal LOS. LgtE is believed to perform the first step in LOS biosynthesis.
(108) POLA2 (11q13.1)
https://www.ncbi.nlm.nih.gov/gene/23649
(DNA polymeraasin alfa2 lisäalayksikkö)
DNA polymerase alpha 2, accessory subunit.
(176) PKP2 (12p11.21)
plakofiliini2 (placophilin 2)
https://www.ncbi.nlm.nih.gov/gene/5318
Plakophilin 2. Also known as ARVD9.
Summary. This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This gene product may regulate the signaling activity of beta-catenin. Two alternately spliced transcripts encoding two protein isoforms have been identified. A processed pseudogene with high similarity to this locus has been mapped to chromosome 12p13. [provided by RefSeq, Jul 2008]Expression Biased expression in heart (RPKM 72.8), colon (RPKM 29.6) and 12 other tissues
(useita armadillo-toistoja)
armadillo repeat
Armadillo
(ARM)/beta-catenin-like repeats are approximately 40 amino acid long,
tandemly repeated sequence motif, first identified in the Drosophila
segment polarity gene armadillo. These repeats were also found in the
mammalian armadillo homolog beta-catenin, the junctional plaque protein
plakoglobin, the adenomatous polyposis coli (APC) tumor suppressor
protein, and a number of other proteins. ARM has been implicated in
mediating protein-protein interactions, but no common features among the
target proteins recognized by the ARM repeats have been identified. ARM
repeats are related to HEAT repeats.ORIGIN 1 maapgapaey gyirtvlgqq ilgqldsssl alpseaklkl agssgrggqt vkslriqeqv 61 qqtlarkgrs svgngnlhrt ssvpeyvynl hlvendfvgg rspvpktydm lkagttatye 121 grwgrgtaqy ssqksveers lrhplrrlei spdssperah ythsdyqysq rsqaghtlhh 181 qesrraallv ppryarseiv gvsragttsr qrhfdtyhrq yqhgsvsdtv fdsipanpal 241 ltyprpgtsr smgnlleken yltagltvgq vrplvplqpv tqnrasrssw hqssfhstrt 301 lreagpsvav dssgrrahlt vgqaaaggsg nllterstft dsqlgnadme mtleravsml 361 eadhmlpsri saaatfiqhe cfqksearkr vnqlrgilkl lqllkvqned vqravcgalr 421 nlvfedndnk levaelngvp rllqvlkqtr dletkkqitg llwnlssndk lknlmiteal 481 ltlteniiip fsgwpegdyp kanglldfdi fynvtgclrn mssagadgrk amrrcdglid 541 slvhyvrgti adyqpddkat encvcilhnl syqleaelpe kysqniyiqn rniqtdnnks 601 igcfgsrsrk vkeqyqdvpm peeksnpkgv ewlwhsivir mylsliaksv rnytqeaslg 661 alqnltagsg pmptsvaqtv vqkesglqht rkmlhvgdps vkktaisllr nlsrnlslqn 721 eiaketlpdl vsiipdtvps tdlliettas acytlnniiq nsyqnardll ntggiqkima 781 isagdayasn kaskaasvll yslwahtelh haykkaqfkk tdfvnsrtak ayhslkd //
Inga kommentarer:
Skicka en kommentar