Sars-2 Envelope E proteiinin interaktioproteiinit: (6) kuusi ihmisen proteiinia

ORF4    (Envelope,    small membrane protein),

https://www.uniprot.org/uniprot/P0DTC4

Interaction

subunit

Homopentamer. Interacts with membrane protein M in the budding compartment of the host cell, which is located between endoplasmic reticulum and the Golgi complex. Interacts with Nucleoprotein (By similarity). Interacts with the accessory proteins 3a and 7a. Interacts (via C-terminus) with human MPP5 (via PDZ domain); this inhibits the interaction between human MPP5 and human CRB3, and causes delayed tight junction formation and defective cell polarity (By similarity)

P0DTC4 · VEMP_SARS2
(75 residues)

Envelope small membrane protein (E protein): Plays a central role in virus morphogenesis and assembly. Acts as a viroporin and self-assembles in host membranes forming pentameric protein-lipid pores that allow ion transport. Also plays a role in the induction of apoptosis.
Model quality estimates are low - use with care.
See here for available low quality models.

UniRule annotation. 

Interaction proteins in host cells :

Links 'A'	Molecule   'B'

https://www.ncbi.nlm.nih.gov/gene/8546

P0DTC4 EBI-25475850

AP3B1

https://www.sahlgrenska.se/for-dig-som-ar/vardgivare/laboratoriemedicin/analyslista/ap3b1/

P0DTC4 EBI-25475850

BRD4

https://www.ncbi.nlm.nih.gov/gene/234764

P0DTC4 EBI-25475850

BRD2

https://www.ncbi.nlm.nih.gov/gene/6046 

   https://www.ncbi.nlm.nih.gov/gene/?term=CWC27

P0DTC4 EBI-25475850

CWC27

 https://www.uniprot.org/uniprot/D6REK3

 https://www.ncbi.nlm.nih.gov/gene/124245 (CCCH type ZNF)

P0DTC4 EBI-25475850

ZC3H18

 https://www.ncbi.nlm.nih.gov/gene/57153

P0DTC4 EBI-25475850

SLC44A2