SARS-2 tekee interaktioita ainakin yli 300 ihmisen proteiiniin

 
Katson  tänään lukemastani interaktioproteiiniluettelosta muutaman interaktioproteiinin. ensin otsikkona SARS-2 proteiini ja alla  jokunen ihmisen interaktioiproteiini ( ihmisen proteiinin geeni mainittuna) Keskeneräinen ...

• SARS-2 nsp8: 

MRPS5 (2q11.1)
https://www.ncbi.nlm.nih.gov/gene/6496
Also known as S5mt; MRP-S5.Summary Mammalian mitochondrial ribosomal proteins(MRP-S)  are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S5P family. Pseudogenes corresponding to this gene are found on chromosomes 4q, 5q, and 18q. [provided by RefSeq, Jul 2008] Expression Ubiquitous expression in kidney (RPKM 9.5), duodenum (RPKM 9.0) and 25 other tissues.
https://string-db.org/network/9606.ENSP00000272418

MRSP27
MRSP2
MRSP25 

•  SARS-2 nsp12:

USP54  (10q32.2)   deubikitinaasi USP ryhmätsä, ubikitiinispesifinen peptidaasi  54

(Näissä  Deubikitinaaseissa DUB, ainakin joissain niistä,   tapaa olla entsyymifunktiolle tärkeä  ZnF- rakenne, vaikka se ei ole proteiinin struktuurissa erityisesti  mainittu) .
https://www.ncbi.nlm.nih.gov/gene/159195
 https://doi.org/10.1002/pro.2415

PRRC2B (9q34.13),  isohko peptidi, jossa on runsaasti  proliineja ja fosforylaatiokohtia. Tämän proteiinin  kliinisestä  merkityksestä on muutama maininta.

 Proline Rich Coiled-Coil 2B ^{2 3 5}

KIAA0515 ^{2 3 4}  , HLA-B-Associated Transcript 2-Like 1 ^{3 4}
Proline-Rich Coiled-Coil Protein 2B ^{3 4}
HLA-B Associated Transcript 2-Like ^{2 3}
Protein PRRC2B ^{3 4}
BAT2L1 ^{3 4}
BAT2L ^{3 4}
HLA-B Associated Transcript 2-Like 1 ²
Proline-Rich Coiled-Coil 2B ²
Protein BAT2-Like 1 ³
LQFBS-1 ³

GeneCards Summary for PRRC2B Gene

PRRC2B (Proline Rich Coiled-Coil 2B) is a Protein Coding gene. Diseases associated with PRRC2B include Spinocerebellar Ataxia, Autosomal Recessive, With Axonal Neuropathy 2 and Spinocerebellar Ataxia 36. An important paralog of this gene is PRRC2C.

•  SARS-2 nsp13

FYCO1,  ZFYVE7 (3p21.31)  FYVE-tyyppinen sinkkisormiproteiini.
https://www.ncbi.nlm.nih.gov/gene/79443
(ZFYVE ryhmän Zn finger rakenne  on C-x-C-x-C-x-C-xxx-C-x-C-H-x-C)
FYCO1, Also known as  CATC2; RUFY3; ZFYVE7; CTRCT18 Summary: This gene encodes a protein that contains a RUN domain, FYVE-type zinc finger domain and Golgi dynamics (GOLD) domain. The encoded protein plays a role in microtubule plus end-directed transport of autophagic vesicles through interactions with the small GTPase Rab7, phosphatidylinositol-3-phosphate (PI3P) and the autophagosome marker LC3. Mutations in this gene are a cause of autosomal recessive congenital cataract-2 (CATC2). [provided by RefSeq, Dec 2011]Expression  Ubiquitous expression in heart (RPKM 22.7), endometrium (RPKM 12.6) and 25 other tissues.


CEP350 (1q25.2)  ( 350 kDa) Sentrosomaalinen proteiini350.

Also known as

GM133; CAP350

Summary  The product of this gene is a large protein with a CAP-Gly domain typically found in cytoskeleton-associated proteins. The encoded protein primarily localizes to the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. The encoded protein directly interacts with another large centrosomal protein and is required to anchor microtubules at the centrosome. It is also implicated in the regulation of a class of nuclear hormone receptors in the nucleus. Several alternatively spliced transcript variants have been found, but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]  https://www.ncbi.nlm.nih.gov/pubmed/17878239/ 

• SARS-2 nsp14:

Sirtuiini SIRT5 (6p23) https://www.ncbi.nlm.nih.gov/gene/23408 This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class III of the sirtuin family. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2010] Expression Ubiquitous expression in heart (RPKM 3.7), liver (RPKM 2.6) and 25 other tissues

 Sinkkiä sitova motiivi: C-xx-C-x(11) -C -x(12)C

  Site            order(166,169,181,194)
                     /site_type="other"
                     /note="Zn binding site [ion binding]"
                     /db_xref="CDD:238703"

• SARS-2 M:

SLC25A21, MTDPS18, ODC, ODC1    https://www.ncbi.nlm.nih.gov/gene/89874

Preferred Names  mitochondrial 2-oxodicarboxylate carrier. Names  oxodicarboxylate carrier solute carrier family 25 (mitochondrial oxoadipate carrier);  member 21; solute carrier family 25 (mitochondrial oxodicarboxylate carrier), member 21.

HIV-1 Vif downregulates the expression of solute carrier family 25, member 21 (SLC25A21) in Vif-expression T cells