SARS-2 ORF3a interaktioproteiinit

P0DTC3 · AP3A_SARS2
(275 residues)

Protein 3a:Forms homotetrameric potassium sensitive ion channels (viroporin) and may modulate virus release. Up-regulates expression of fibrinogen subunits FGA, FGB and FGG in host lung epithelial cells. Induces apoptosis in cell culture. Downregulates the type 1 interferon receptor by inducing serine phosphorylation within the IFN alpha- receptor subunit 1 (IFNAR1) degradation motif and increasing IFNAR1 ubiquitination.
Only remote homologues were identified as potential template structures, limiting the expected quality of the models.

ORF3a INTERAKTIOPROTEIINIT äässä taulukossa ovat

1. VPS39,     HOPS complex subunit
2. ALG5,      Dolichyl-phosphate beta-glucosyl transferase
3. TRIM59,   Tripartite motif containing 59
4. CLCC1,    Chloride channel CLIC-like 1
5. ARL6IP6, ADP ribosylation factor-like  GTPase6 interacting protein
6. VPS11,     VPS, CORVET/HOPS  core subunit
7. HMOX1,  Heme oxydase1
8. SUN2,      Sad1 and UNC84 domain conaining2

Swiss model

		https://www.ebi.ac.uk/intact/interactors/id:P0DTC3* Names	Type	Interactions	Links		Accession	Description
	1	tri59_human	protein	1	EBI-10262539		EBI-10262539	Tripartite motif-containing protein 59
	2	sun2_human	protein	1	EBI-1044964		EBI-1044964	SUN domain-containing protein 2
	3	vps39_human	protein	1	EBI-1050197		EBI-1050197	Vam6/Vps39-like protein
	4	alg5_human	protein	1	EBI-11725055		EBI-11725055	Dolichyl-phosphate beta-glucosyltransferase
	5	orf3a_wcpv	protein	8	EBI-25475894		EBI-25475894	Protein 3a
	6	hmox1_human	protein	1	EBI-2806151		EBI-2806151	Heme oxygenase 1
	7	ar6p6_human	protein	1	EBI-2808844		EBI-2808844	ADP-ribosylation factor-like protein 6-interacting protein 6
	8	clcc1_human	protein	1	EBI-2836109		EBI-2836109	Chloride channel CLIC-like protein 1
	9	vps11_human	protein	1	EBI-373380		EBI-373380	Vacuolar protein sorting-associated protein 11 homolog