On mainittu muutamisas artikkeleissa lehdistössä, että virus aiheutta tuskatiloja, paniikkia ja myös konfuusiota, jotka kyllä ovat ohimeneviäkin toipuneilla. Neurologisista jälkitgaudeista on liian varhaista sanoa mitään. Kova väsymys kuuluu tulehdukseen.
Pari vanhaa tietoa koronavirusten neurotropismista netistä googlaamalla:
Neuroinvasive and neurotropic human respiratory ... - NCBI
av M Desforges - 2014 - Citerat av 11 - Relaterade artiklar
Neuroinvasive and neurotropic human respiratory coronaviruses: potential ... respiratory distress syndrome, or even severe acute respiratory syndrome (SARS
In humans, viral
infections of the respiratory tract are a leading cause of morbidity and
mortality worldwide. Several recognized respiratory viral agents have a
neuroinvasive capacity since they can spread from the respiratory tract
to the central nervous system (CNS). Once there, infection of CNS cells
(neurotropism) could lead to human health problems, such as
encephalitis and long-term neurological diseases. Among the various
respiratory viruses, coronaviruses are important pathogens of humans and
animals. Human Coronaviruses (HCoV) usually infect the upper
respiratory tract, where they are mainly associated with common colds.
However, in more vulnerable populations, such as newborns, infants, the
elderly, and immune-compromised individuals, they can also affect the
lower respiratory tract, leading to pneumonia, exacerbations of asthma,
respiratory distress syndrome, or even severe acute respiratory syndrome
(SARS). The respiratory involvement of HCoV has been clearly
established since the 1960s. In addition, for almost three decades now,
the scientific literature has also demonstrated that HCoV are
neuroinvasive and neurotropic and could induce an overactivation of the
immune system, in part by participating in the activation of
autoreactive immune cells that could be associated with autoimmunity in
susceptible individuals. Furthermore, it was shown that in the murine
CNS, neurons are the main target of infection, which causes these
essential cells to undergo degeneration and eventually die by some form
of programmed cell death after virus infection. Moreover, it appears
that the viral surface glycoprotein (S) represents an important factor
in the neurodegenerative process. Given all these properties, it has
been suggested that these recognized human respiratory pathogens could
be associated with the triggering or the exacerbation of neurological
diseases for which the etiology remains unknown or poorly understood.
Neurotropic coronavirus infections - ResearchGate
Neurotropism and neuroinvasiveness have also has been described for two other members of the Coronaviridae family, HCoV-OC43 and SARS-coronavirus
(Jokin vanha koronavirus oli varsin neurotrooppinen Viruksen hepatiitti-koronavirus on osoitautunutoelvan hyvä koe-eläinmalli myös mahdollisista enkefaliiteista ja demyelinisoivista seuraamuksista. Ihmisellä havaittiin tämän alunperin vain talvallisia vilustumisa aiheuttavan viruksen
mahdollisuus päästä aivoihin tekemään enkefaliitteja. ne taas voivat oolla eri asteisia, lievissä virus puhdistuu vähitellen itsestään eikä jätä jälkitauteja. Joissain tapauksissa myelinisaatiohäiriö progredioituu ja enkefaliitti voi olla hengenvaarallinen. ne ihmisvirukset mitkä ensimmäistä kertaa liitettiin neurotrooppisuuteen olivat varhain jo 1960 luvulla löydetyt embecovirus betakoronavirus HCoV-OC43 ja HCoV-229E, Duvinavirus, alfakoronavirus . Myös aiemmasta SARS CoV virukssta maintian neurotrooppisuutta.
Abstract
Introduction/classification
Mouse hepatitis virus (MHV) is a member of the Coronaviridae family in
the order Nidovirales. Coronaviruses are classified into one of three
antigenic groups, with MHV classified as a member of group 2 [1].
Members of the Coronaviridae family infect a wide range of species
including humans, cows, pigs, chickens, dogs, cats, bats, and mice. In
addition to causing clinically relevant disease in humans ranging from
mild upper respiratory infection (e.g., HCoV [human coronavirus]-OC43
and HCoV-229E responsible for a large fraction of common colds) to
severe acute respiratory syndrome (SARS) [2, 3], coronavirus infections
in cows, chickens, and pigs exact a significant annual economic toll on
the livestock industry. MHV is a natural pathogen of mice that generally
is restricted to replication within the gastrointestinal tract [4, 5].
However, there exist several laboratory strains of MHV that have adapted
to replicate efficiently in the central nervous system (CNS) of mice
and other rodents. Depending on the strain of MHV, virulence and
pathology ranges from mild encephalitis with subsequent clearance of the
virus and the development of demyelination to rapidly fatal
encephalitis.
Thus, the neurotropic strains of MHV have proved to be
useful systems in which to study processes of virus- and immune-mediated
demyelination, virus clearance and/or persistence in the CNS, and
mechanisms of virus evasion from the immune system.
Neurotropism and
neuroinvasiveness have also has been described for two other members of
the Coronaviridae family, HCoV-OC43 and SARS-coronavirus (CoV) (Table
4.1). © Cambridge University Press 2008 and Cambridge University Press,
2009.
Inga kommentarer:
Skicka en kommentar