ACE2 on reseptori koronaviruksen S- pintaproteiinille.

https://www.ncbi.nlm.nih.gov/gene/59272

Preferred Names

angiotensin-converting enzyme 2

Names

ACE-related carboxypeptidase

angiotensin I converting enzyme (peptidyl-dipeptidase A) 2

angiotensin-converting enzyme homolog

metalloprotease MPROT15

peptidyl-dipeptidase A

 https://www.ncbi.nlm.nih.gov/nuccore/NC_000023.11?from=15561905&to=15600911&strand=2

 
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Related articles in PubMed

1. Hypertension and hypertensive left ventricular hypertrophy are associated with ACE2 genetic polymorphism. Fan Z, et al. Life Sci, 2019 May 15. PMID 30917908
2. RhoA-Rho associated kinase signaling leads to renin-angiotensin system imbalance and angiotensin converting enzyme 2 has a protective role in acute pulmonary embolism. Xu X, et al. Thromb Res, 2019 Apr. PMID 30784777
3. A review of urinary angiotensin converting enzyme 2 in diabetes and diabetic nephropathy. Gilbert A, et al. Biochem Med (Zagreb), 2019 Feb 15. PMID 30591810, Free PMC Article
4. Evidence for a role of angiotensin converting enzyme 2 in proteinuria of idiopathic nephrotic syndrome. Filha RDS, et al. Biosci Rep, 2019 Jan 31. PMID 30514826, Free PMC Article
5. Fetal But Not Maternal Angiotensin Converting Enzyme (ACE)-2 Gene Rs2074192 Polymorphism is Associated with Increased Risk of Being a Small For Gestational Age (SGA) Newborn. He J, et al. Kidney Blood Press Res, 2018. PMID 30347406

See all (265) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

1. A strong association of circulating miR-421 with decreased transcripts of ACE2 may contribute to the low expression of the enzyme in leukocytes of chronic kidney disease patients
2. RhoA-ROCK signaling leads to renin-angiotensin system imbalance in acute pulmonary embolism patients, and ACE2 activation might be a novel therapeutic target in acute pulmonary embolism treatment.
3. Our findings suggest that ACE2, as a potential resister to breast cancer, might inhibit breast cancer angiogenesis through the VEGFa/VEGFR2/ERK pathway.
4. We have hypothesized the mechanism that reverses the downregulation of the ACE2-angiotensin 1-7/Mas receptor axis path and the upregulation of angiotensin receptor type 1-mediated signaling. Thus, we posit that ACE2, Ang-(1-7), and the Mas receptor could be novel therapeutic targets for treating benign prostatic hyperplasia
5. Evidence for a role of ACE2 in pediatric proteinuria of idiopathic nephrotic syndrome has been presented.
6. Urinary ACE2, neprilysin, and ADAM17 are increased in patients with diabetes and could be used as early biomarkers to predict the incidence or progression of CKD at early stages among individuals with type 2 diabetes.
7. ACE2 genetic polymorphisms are associated with hypertension and hypertensive left ventricular hypertrophy.
8. REVIEW: recent findings on expression of urinary ACE2, examination of its relationship with clinical parameters and highlights possible applications in management of diabetic nephropathy
9. down-regulation of lncRNA GAS5 decreases ACE2 expression through increasing miR-200c-3p to promote the apoptosis of A549 cells, thus to promote the progression of acute respiratory distress syndrome
10. ACE2 SNP rs879922 may be a common genetic loci and optimal genetic susceptibility marker for type 2 diabetes and related cardiovascular risks in Uygurs.
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    https://physoc.onlinelibrary.wiley.com/doi/full/10.1113/expphysiol.2007.040048

    Abstract

    During several months of 2002, severe acute respiratory syndrome (SARS) caused by SARS‐coronavirus (SARS‐CoV) spread rapidly from China throughout the world, causing more than 800 deaths due to the development of acute respiratory distress syndrome (ARDS), which is the severe form of acute lung injury (ALI). Interestingly, a novel homologue of angiotensin‐converting enzyme, termed angiotensin‐converting enzyme 2 (ACE2), has been identified as a receptor for SARS‐CoV. Angiotensin‐converting enzyme and ACE2 share homology in their catalytic domain and provide different key functions in the renin–angiotensin system (RAS). Angiotensin‐converting enzyme cleaves angiotensin I to generate angiotensin II, which is a key effector peptide of the system and exerts multiple biological functions, whereas ACE2 reduces angiotensin II levels. Importantly, our recent studies using ACE2 knockout mice have demonstrated that ACE2 protects murine lungs from ARDS. Furthermore, SARS‐CoV infections and the Spike protein of the SARS‐CoV reduce ACE2 expression. Notably, injection of SARS‐CoV Spike into mice worsens acute lung failure in vivo, which can be attenuated by blocking the renin–angiotensin pathway, suggesting that the activation of the pulmonary RAS influences the pathogenesis of ALI/ARDS and SARS.
     The renin–angiotensin system (RAS) plays a central role in the control of cardiovascular and renal functions by maintaining the physiological homeostasis of blood pressure and electrolyte balance. Abnormal activation of the RAS has been associated with the pathogenesis of cardiovascular and renal diseases such as hypertension, myocardial infarction and heart failure (Ferrario, 1990; Nicholls et al. 1998; Fleming et al. 2006). The protease renin cleaves angiotensinogen to generate angiotensin (Ang) I. Angiotensin‐converting enzyme (ACE) cleaves Ang I to produce Ang II, which is a key regulator of the RAS and exerts biological functions through the specific receptors Ang II receptor type 1 (AT₁R) and Ang II receptor type 2 (AT₂R; Skeggs et al. 1980; Corvol et al. 1995). Thus, for many years, ACE has been known as the key enzyme in the regulation of the RAS (Skeggs et al. 1980; Turner & Hooper, 2002; Fig. 1).