INFgamma interferoni ja sen reseptoridimeeri IFNGR1/ IFNGR2

• https://www.ncbi.nlm.nih.gov/gene/3458

IFNG (12q15) IFN gamma interferoni.

• Gammainterferonin reseptorit  muodostavat heterodimeerin IFNGR1 ja IFNG2.

Lisätietoa  IFNGR1  reseptoriosasta:

IFNGR1 (6q23.2), CD119, IMD27A, IMD27B.
https://www.ncbi.nlm.nih.gov/gene/3459 

Official Symbol

IFNGR1provided by HGNC

Official Full Name

interferon gamma receptor 1provided by HGNC

Also known as

CD119; IFNGR; IMD27A; IMD27B

Summary

This gene (IFNGR1) encodes the ligand-binding chain (alpha) of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. A genetic variation in IFNGR1 is associated with susceptibility to Helicobacter pylori infection. In addition, defects in IFNGR1 are a cause of mendelian susceptibility to mycobacterial disease, also known as familial disseminated atypical mycobacterial infection. [provided by RefSeq, Jul 2008]

Expression

Ubiquitous expression in spleen (RPKM 51.4), fat (RPKM 48.1) and 25 other tissues See more

Preferred Names

interferon gamma receptor 1

Names

AVP, type 2

CD119 antigen

CDw119

IFN-gamma receptor 1

IFN-gamma-R-alpha

IFN-gamma-R1

antiviral protein, type 2

immune interferon receptor 1

interferon-gamma receptor alpha chain

(.... IFNGR1 rakenteesta ) (1..489 aminohappoa)
https://www.ncbi.nlm.nih.gov/protein/NP_000407.1

( 25.. 113)  "FN3"
(161..317 ) (Reseptorikohta)

Interferon gamma receptor (IFNGR1)

This family consists of several eukaryotic and viral interferon gamma receptor proteins. Molecular interactions among cytokines and cytokine receptors in eukaryotes form the basis of many cell-signaling pathways relevant to immune function. Human interferon-gamma (IFN-gamma) signals through a multimeric receptor complex consisting of two different but structurally related transmembrane chains: the high-affinity receptor-binding subunit (IFN-gammaRalpha) and a species specific accessory factor (AF-1 or IFN-gammaRbeta). The vaccinia viral interferon gamma receptor has been shown to be secreted from infected cells during early infection. The structure has been halved such that the N-terminus of this family is now represented by Tissue_fac pfam01108.

 N-Glycosylation sites 34N, 79N, 86N, 179N, 240N
 246-266  TM domain ( transmembraaninen kohta) 
Phosphorylation sites   372T, 378S, 403S
Huom tässä on tumareseptorisignaali lvdll, koska tämä osa voi mennä tumaan aktivoidun  STAT1dimeerin kanssa. Katso reseptorin kuvaa ja selitystä. 

ORIGIN      
        1 mallfllplv mqgvsraemg tadlgpssvp tptnvtiesy nmnpivywey qimpqvpvft
       61 vevknygvkn sewidacini shhycnisdh vgdpsnslwv rvkarvgqke sayakseefa
      121 vcrdgkigpp kldirkeekq imidifhpsv fvngdeqevd ydpettcyir vynvyvrmng
      181 seiqykiltq keddcdeiqc qlaipvssln sqycvsaegv lhvwgvttek skevcitifn
      241 ssikgslwip vvaalllflv lslvficfyi kkinplkeks iilpkslisv vrsatletkp
      301 eskyvslits yqpfslekev vceeplspat vpgmhtednp gkvehteels sitevvttee
      361 nipdvvpgsh ltpieresss plssnqsepg sialnsyhsr ncsesdhsrn gfdtdsscle
      421 shsslsdsef ppnnkgeikt egqelitvik aptsfgydkp hvlvdllvdd sgkesligyr
      481 ptedskefs
//

Lisätietoa  IFNGR2  reseptorigeenistä
https://www.ncbi.nlm.nih.gov/gene/3460

Also known as

AF-1; IFGR2; IMD28; IFNGT1

Summary

This gene (IFNGR2) encodes the non-ligand-binding beta chain of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. Defects in IFNGR2 are a cause of mendelian susceptibility to mycobacterial disease (MSMD), also known as familial disseminated atypical mycobacterial infection. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant or X-linked inheritance. [provided by RefSeq, Jul 2008]

Expression

Ubiquitous expression in placenta (RPKM 30.0), appendix (RPKM 25.4) and 25 other tissues See more

Preferred Names

interferon gamma receptor 2

Names

IFN-gamma receptor 2

IFN-gamma-R-beta

IFN-gamma-R2

interferon gamma receptor accessory factor-1 (AF-1)

interferon gamma receptor beta chain

interferon gamma transducer 1, (IFNGT1)

 

Ref.  " Data suggest IFNG plays various roles in dynamics of inflammation in subjects with underlying autoimmunity modeled as "canonical" and "non-canonical" pathways; in canonical pathway, IFNG dimerizes and binds to IFNGR1 in IFNGR1/IFNGR2 hetero-multimer; STAT transcription factors are involved in non-canonical pathway. (IFNG = interferon gamma; IFNGR = IFNG receptor; STAT = signal transducers and activators of transcription)"

 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5572907/

(FIGURE!) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5572907/figure/F2/

 https://www.ncbi.nlm.nih.gov/protein/?term=Homo+sapiens+IFNGR2
ja rakenteesta yksityiskohtia 
 https://www.ncbi.nlm.nih.gov/protein/NP_001316057.1
IFNGR2, AF-1, INFGR2, IFNGT1 IMP28
(21q22.11) 
Rakenne: (1..356)
47..145 "FN3"
158..256 ""FN3"

ORIGIN      
        1 mrptllwsll lllgvfaaaa aappaqltle tyqewcndsa athdplsqlp apqhpkirly
       61 naeqvlswep valsnstrpv vyqvqfkytd skwftadims igvnctqita tecdftaasp
      121 sagfpmdfnv tlrlraelga lhsawvtmpw fqhyrnvtvg ppenievtpg egsliirfss
      181 pfdiadtsta ffcyyvhywe kggiqqvkgp frsnsisldn lkpsrvyclq vqaqllwnks
      241 nifrvghlsn iscyetmada stelqqvili svgtfsllsv lagacfflvl kyrglikywf
      301 htppsiplqi eeylkdptqp ilealdkdss pkddvwdsvs iisfpekeqe dvlqtl
//