Kissan viruksissa FECV ja FIP välillä tapahtuvienmutaatioiden merkitys: 3c geeni patotyypin n merkitsijä

https://www.ncbi.nlm.nih.gov/pubmed/?term=FECV+mutation+to+FIP+feline+coronavirus
FECV pysyttelee  suolistossa, muta  kun se on mutatoitunut FIP muotoon se on  vaihtanut aitiota ja infektoi monosyytejä, tauti on systeemisempi ja vakavampi.   Tästä  referaatteja linkkejä:
https://www.ncbi.nlm.nih.gov/pubmed/?term=FECV+mutation+to+FIP+feline+coronavirus

Best matches for FECV mutation to FIP feline coronavirus:

Feline Coronaviruses: Pathogenesis of Feline Infectious Peritonitis. Tekes G et al. Adv Virus Res. (2016)
 

Sensitivity and specificity of a real-time reverse transcriptase polymerase chain reaction detecting feline coronavirus mutations in effusion and serum/plasma of cats to diagnose feline infectious peritonitis. Felten S et al. BMC Vet Res. (2017)
 

Limitations of using feline coronavirus spike protein gene mutations to diagnose feline infectious peritonitis. Barker EN et al. Vet Res. (2017)

Prevalence and mutation analysis of the spike protein in feline enteric coronavirus and feline infectious peritonitis detected in household and shelter cats in western Canada.

McKay LA, Meachem M, Snead E, Brannen T, Mutlow N, Ruelle L, Davies JL, van der Meer F.

Can J Vet Res. 2020 Jan;84(1):18-23.

PMID:

31949325

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Select item 317298972.

Feline coronavirus with and without spike gene mutations detected by real-time RT-PCRs in cats with feline infectious peritonitis.

Emmler L, Felten S, Matiasek K, Balzer HJ, Pantchev N, Leutenegger C, Hartmann K.

J Feline Med Surg. 2019 Nov 15:1098612X19886671. doi: 10.1177/1098612X19886671. [Epub ahead of print]

PMID:

31729897

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Select item 315347753.

Distinct mutation in the feline coronavirus spike protein cleavage activation site in a cat with feline infectious peritonitis-associated meningoencephalomyelitis.

André NM, Cossic B, Davies E, Miller AD, Whittaker GR.

JFMS Open Rep. 2019 Jun 26;5(1):2055116919856103. doi: 10.1177/2055116919856103. eCollection 2019 Jan-Jun.Case summary:

This report describes a cat with chronic, progressive, non-painful, non-lateralizing multifocal neurologic clinical signs associated with feline infectious peritonitis (FIP). The cat initially presented as underweight, despite a good appetite, and a complete blood count showed non-regenerative anemia. Three months later the cat was returned having developed ataxia and paraparesis, which then progressed over 2 months to tetraparesis, tail plegia, urinary and fecal incontinence, and titubation. Histologic examination of the tissues with subsequent immunohistochemistry confirmed FIP-associated meningoencephalomyelitis following necropsy. Molecular analysis of the coronavirus spike protein within the tissues identified a specific, functionally relevant amino acid change (R793M), which was only identified in tissues associated with the central nervous system (ie, brain and spinal cord). Relevance and novel information:
This case report describes an early presentation of a cat with primarily neurologic FIP, with molecular characterization of the virus within various tissues.

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Select item 314474574.

Feline coronavirus isolates from a part of Brazil: insights into molecular epidemiology and phylogeny inferred from the 7b gene.

Myrrha LW, Silva FMF, Vidigal PMP, Resende M, Bressan GC, Fietto JLR, Santos MR, Silva LMN, Assao VS, Silva-Jú Nior A, de Almeida MR.

J Vet Med Sci. 2019 Oct 18;81(10):1455-1460. doi: 10.1292/jvms.19-0090. Epub 2019 Aug 23.Abstract

The Feline coronavirus (FCoV) can lead to Feline infectious peritonitis (FIP), which the precise cause is still unknown. The theory of internal mutation suggests that a less virulent biotype of FCoV (FECV) would lead to another more pathogenic biotype (FIPV) capable of causing FIP.
 In this work, the 7b gene was amplified from 51 domestic cat plasma samples by semi-nested PCR and tested through phylogenetic and phylogeographical approaches. The 7b gene of Brazilian isolates displayed high conservation, a strong correlation between the geographic origin of the viral isolates and their genealogy, and its evolution was possibly shaped by a combination of high rates of nucleotide substitution and purifying selection.

Free PMC Article

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Select item 302631435.

First identification of a single amino acid change in the spike protein region of feline coronavirus detected from a coronavirus-associated cutaneous nodule in a cat.

Osumi T, Mitsui I, Leutenegger CM, Okabe R, Ide K, Nishifuji K.

JFMS Open Rep. 2018 Sep 20;4(2):2055116918801385. doi: 10.1177/2055116918801385. eCollection 2018 Jul-Dec.PMID:

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Select item 289823906.

Limitations of using feline coronavirus spike protein gene mutations to diagnose feline infectious peritonitis.

Barker EN, Stranieri A, Helps CR, Porter EL, Davidson AD, Day MJ, Knowles T, Kipar A, Tasker S.

Vet Res. 2017 Oct 5;48(1):60. doi: 10.1186/s13567-017-0467-9.

Free PMC Article

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Select item 287685147.

Sensitivity and specificity of a real-time reverse transcriptase polymerase chain reaction detecting feline coronavirus mutations in effusion and serum/plasma of cats to diagnose feline infectious peritonitis.

Felten S, Leutenegger CM, Balzer HJ, Pantchev N, Matiasek K, Wess G, Egberink H, Hartmann K.

BMC Vet Res. 2017 Aug 2;13(1):228. doi: 10.1186/s12917-017-1147-8.

Free PMC Article

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Select item 277126248.

Feline Coronaviruses: Pathogenesis of Feline Infectious Peritonitis.

Tekes G, Thiel HJ.

Adv Virus Res. 2016;96:193-218. doi: 10.1016/bs.aivir.2016.08.002. Epub 2016 Aug 31. Review.

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Select item 272430379.

Feline Coronavirus 3c Protein: A Candidate for a Virulence Marker?

Hora AS, Tonietti PO, Taniwaki SA, Asano KM, Maiorka P, Richtzenhain LJ, Brandão PE.

Biomed Res Int. 2016;2016:8560691. doi: 10.1155/2016/8560691. Epub 2016 May 3.Abstract

Feline infectious peritonitis virus (FIPV) is highly virulent and responsible for the highly fatal disease feline infectious peritonitis (FIP), whereas feline enteric coronavirus (FECV) is widespread among the feline population and typically causes asymptomatic infections. Some candidates for genetic markers capable of differentiating these two pathotypes of a unique virus (feline coronavirus) have been proposed by several studies. In the present survey, in order to search for markers that can differentiate FECV and FIPV, several clones of the 3a-c, E, and M genes were sequenced from samples obtained from cats with or without FIP. All genes showed genetic diversity and suggested the presence of FCoV mutant spectrum capable of producing a virulent pathotype in an individual-specific way. In addition, all the feline coronavirus FIPV strains demonstrated a truncated 3c protein, and the 3c gene was the only observed pathotypic marker for FCoVs, showing that 3c gene is a candidate marker for the distinction between the two pathotypes when the mutant spectrum is taken into account.

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Select item 2702731610.

Reversal of the Progression of Fatal Coronavirus Infection in Cats by a Broad-Spectrum Coronavirus Protease Inhibitor.

Kim Y, Liu H, Galasiti Kankanamalage AC, Weerasekara S, Hua DH, Groutas WC, Chang KO, Pedersen NC.

PLoS Pathog. 2016 Mar 30;12(3):e1005531. doi: 10.1371/journal.ppat.1005531. eCollection 2016 Mar. Erratum in: PLoS Pathog. 2016 May;12(5):e1005650.

Coronaviruses infect animals and humans causing a wide range of diseases. The diversity of coronaviruses in many mammalian species is contributed by relatively high mutation and recombination rates during replication. This dynamic nature of coronaviruses may facilitate cross-species transmission and shifts in tissue or cell tropism in a host, resulting in substantial change in virulence. Feline enteric coronavirus (FECV) causes inapparent or mild enteritis in cats, but a highly fatal disease, called feline infectious peritonitis (FIP), can arise through mutation of FECV to FIP virus (FIPV). The pathogenesis of FIP is intimately associated with immune responses and involves depletion of T cells, features shared by some other coronaviruses like Severe Acute Respiratory Syndrome Coronavirus. The increasing risks of highly virulent coronavirus infections in humans or animals call for effective antiviral drugs, but no such measures are yet available. Previously, we have reported the inhibitors that target 3C-like protease (3CLpro) with broad-spectrum activity against important human and animal coronaviruses. Here, we evaluated the therapeutic efficacy of our 3CLpro inhibitor in laboratory cats with FIP. Experimental FIP is 100% fatal once certain clinical and laboratory signs become apparent. We found that antiviral treatment led to full recovery of cats when treatment was started at a stage of disease that would be otherwise fatal if left untreated. Antiviral treatment was associated with a rapid improvement in fever, ascites, lymphopenia and gross signs of illness and cats returned to normal health within 20 days or less of treatment. Significant reduction in viral titers was also observed in cats. These results indicate that continuous virus replication is required for progression of immune-mediated inflammatory disease of FIP. These findings may provide important insights into devising therapeutic strategies and selection of antiviral compounds for further development for important coronaviruses in animals and humans.Free PMC Article

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