XM | Germany 30.0%, United Kingdom 23.0%, Denmark 20.0%, Netherlands 13.0%, Croatia 3.0% | 2022-02-14 | 22 | 30 | Recombinant lineage of BA.1.1 and BA.2, European lineage, from pango-designation issue #472 |
Potential BA.1.1/BA.2 Recombinant in the Germany, Netherlands and beyond, with likely breakpoint at NSP13-15 (50 Seqs as of 2022-03-31) #472
Description
Recombinant between: BA.1.1 & BA.2
Earliest sequence: 2022/2/21 (NL-NH)
Most recent sequence: 2022/3/04 (NL-NH)
Countries circulating: Netherlands (NH)
Likely breakpoint: between 17410 and 19995 (NSP13 or NSP14 or NSP15, ORF1b).
Cov-spectrum query: C15240T, C2470T, A18163G, C19955T, A20055G
https://cov-spectrum.org/explore/Netherlands/AllSamples/Past6M/variants?nucMutations=C15240T%2CC2470T%2CA18163G%2CC19955T%2CA20055G
Genomes:
hCoV-19/Netherlands/NH_AUMC-004734/2022 EPI_ISL_10925473 2022-03-04
hCoV-19/Netherlands/NH_AUMC-004178/2022 EPI_ISL_10925492 2022-02-21
Evidence
Output from Lena’s great tool, which can be found here:
https://github.com/lenaschimmel/sarscov2recombinants
(Etsintäkombinaatioitten jälkeen jälkeen tarkentui linjat. Mutaatiokokoomus on alla: ORF1b- kohdalle asettui muutoksia, jotka heijastuivat virusproteiinien rakenteisiin, jos ne olivat ORF1b-alueelta koodattuja.
SITAATTI mutaatioista, joista suurin osa on yleistä omikronrakennetta ja BA.2 sekä BA.1.1. linjatyyppistä.
- •E:T9I (100.00%, 0.00)
- •M:Q19E (97.47%, 0.00)
-
-
- •M:A63T (100.00%, 0.00)
- •N:P13L (100.00%, 0.00)
- •N:E31- (100.00%, 0.00)
- •N:R32- (100.00%, 0.00)
- •N:S33- (100.00%, 0.00)
- •N:R203K (100.00%, 0.00)
- •N:G204R (100.00%, 0.00)
- •N:S413R (100.00%, 0.00)
- •ORF1a:K856R (100.00%, 0.00)
- •ORF1a:S2083- (97.55%, 0.00)
- •ORF1a:L2084I (97.55%, 0.00)
- •ORF1a:A2710T (99.39%, 0.00)
- •ORF1a:T3255I (100.00%, 0.00)
- •ORF1a:P3395H (99.36%, 0.00)
- •ORF1a:L3674- (95.65%, 0.00)
- •ORF1a:S3675- (100.00%, 0.00)
- •ORF1a:G3676- (98.76%, 0.00)
- •ORF1a:I3758V (100.00%, 0.00)
- •ORF1b:P314L (100.00%, 0.00)
- •ORF1b:R1315C (7.88%, 0.00)
- •ORF1b:I1566V (100.00%, 0.00)
- •ORF1b:T2163I (88.54%, 0.00)
- •ORF3a:T223I (97.58%, 0.00)
- •ORF6:D61L (100.00%, 0.00)
- •ORF9b:P10S (100.00%, 0.00)
- •ORF9b:E27- (100.00%, 0.00)
- •ORF9b:N28- (100.00%, 0.00)
- •ORF9b:A29- (100.00%, 0.00)
- •S:T19I (93.04%, 0.00)
- •S:L24- (93.29%, 0.00)
- •S:P25- (93.29%, 0.00)
- •S:P26- (93.29%, 0.00)
- •S:A27S (93.29%, 0.00)
- •S:A67V (5.92%, 0.00)
- •S:H69- (5.92%, 0.00)
- •S:V70- (5.92%, 0.00)
- •S:T95I (7.27%, 0.00)
- •S:G142D (96.32%, 0.00)
- •S:V213G (96.93%, 0.00)
- •S:G339D (100.00%, 0.00)
- •S:S371F (95.60%, 0.00)
- •S:S373P (99.38%, 0.00)
- •S:S375F (99.37%, 0.00)
- •S:T376A (95.57%, 0.00)
- •S:D405N (96.32%, 0.00)
- •S:R408S (95.68%, 0.00)
- •S:K417N (98.73%, 0.00)
- •S:N440K (97.84%, 0.00)
- •S:S477N (100.00%, 0.00)
- •S:T478K (100.00%, 0.00)
- •S:E484A (100.00%, 0.00)
- •S:Q493R (100.00%, 0.00)
- •S:Q498R (99.30%, 0.00)
- •S:N501Y (99.30%, 0.00)
- •S:Y505H (99.29%, 0.00)
- •S:D614G (100.00%, 0.00)
- •S:H655Y (100.00%, 0.00)
- •S:N679K (100.00%, 0.00)
- •S:P681H (98.79%, 0.00)
- •S:N764K (100.00%, 0.00)
- •S:D796Y (100.00%, 0.00)
- •S:Q954H (100.00%, 0.00)
- •S:N969K (100.00%, 0.00)
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