Omikronlinja BA.2.18 on merkattu. omaksi alalinjakseen, jossa on S:N417T

 https://github.com/cov-lineages/pango-designation/issues/528

 

Potential sub-lineage of BA.2 with S:K417T and nuc:C23248T in UK/Ireland (900 seq) #528

 

Olias(nimimerkki) ilmoittaa 17 päivää sitten Britanniassa kiertävästä virusvariantista, jolla on mutaatio  N217 ( gammasta  jo tunnettu. Sillä voi olla  immunoevaasiovaikutusta,  mainitaan tiedemiesten keskustelussa: 

ub lineage of BA.2 with 517 sequences in UK
Contains
S:K417T
A22812C, C23248T
Earliest sequence 2022-02-19 England/ALDP-37C4703/2022

Edit by (nimimerkki  cornelius. ):  70% contains ORF7a:S83L, but there's significant circulation without this mutation

Fairly large potential growth advantage at this stage. 

...

"Oh interesting, convergent evolution with #540 which is a really successful BA.3 lineage with S:417T (Gamma mutation!)

Thanks (nimimerkki olias)  this is a good find - especially the combination of RBD mutation and growth.

.. could you please  use the advanced growth advantage against a BA.2* background? Any BA.2* will have 30% growth advantage simply because it's BA.2*. Also please filter to the country with the highest share - in this case UK. " 

(Nimim. FedeQuei reminds about Orf7a::83L 14 days ago)
Remember that B.1.617.2 (Delta) carry Orf7a:V82A just near that AA. I wouldnt dismiss that mutation as influential (for sure i agree on the designation starting from the nuc you found) and also AY.122 had orf7a:45L and it became the only AY. to reach top ten of more sequenced delta sub- lineages in more than 3 continents.
But maybe, you know, it is just that i am biased versus Orf3a Orf7ab and N mutations ;) 

(Nimim cornelius 6 days ago) 

I just rediscovered this lineage. Was about to propose but then found it again.  (Nimim) Chris R.  could you have a look at designating this one? It has now also been imported into the US and France and keeps growing. It is reasonable that S:417T could help with immune escape.

 (Chris R) Added new lineage BA.2.18 from #528 with 960 new sequence designations

chrisruis  added this to the BA.2.18 milestone 4 days ago

Thanks @olias120676 We've added this as BA.2.18 to start on the branch with A22812C (S:N417T) which is likely the first nonsynonymous mutation in this introduction(s) into the UK