https://www.genecards.org/cgi-bin/carddisp.pl?gene=ERO1B&keywords=ERO1b
Monta nimeä on tälläkin oxidoreduktaasilla:
Endoplasmic Reticulum Oxidoreductase 1 Beta 2 3 5
Endoplasmic Reticulum Oxidoreductin-1-Like Protein B 3 4
Endoplasmic Reticulum Oxidoreductase Beta 3 4
ERO1-Like Protein Beta 3 4
Oxidoreductin-1-L-Beta 3 4
ERO1-L-Beta 3 4
ERO1LB 3 4
Endoplasmic Oxidoreductin-1-Like Protein B 3
ERO1-Like Beta (S. Cerevisiae) 2
ERO1-Like Beta 3
EC 1.8.4.- 4
Ero1beta 3
EC 1.8.4 52
Oxidoreductase involved in disulfide bond
formation in the endoplasmic reticulum. Efficiently reoxidizes P4HB/PDI,
the enzyme catalyzing protein disulfide formation, in order to allow
P4HB to sustain additional rounds of disulfide formation. Other protein
disulfide isomerase family members can also be reoxidized, but at lower
rates compared to P4HB, including PDIA2 (50% of P4HB reoxidation rate),
as well as PDIA3, PDIA4, PDIA6 and NXNDC12 (<10 a="" be="" cell.="" cells="" class="gc-ga-link " electrons="" fad="" folding="" following="" glucose="" hence="" homeostasis.="" href="http://www.uniprot.org/uniprot/Q86YB8#function" in="" involved="" its="" leading="" may="" molecular="" of="" oxidative="" oxygen="" p4hb="" pancreatic="" passes="" play="" production="" proinsulin="" reactive="" reoxidation="" role="" species="" target="_blank" the="" to="" via=""> ERO1B_HUMAN,Q86YB8
ENDOPLASMINEN REDOXTIE: ( endoplasmisessa verkostossa tapahtuvan pelkistämisen ja hapettamisen tie)
Tässä on paljon molekulaarista koneistoa . Löysin yhden artikkelin heti ja se tarjoaa kuvan, jossa tämä Ero1b- molekyyli mainitaan.
(Suom) Endoplasminen verkosto (retikulum) (ER) on pääpaikka, missä eukaryoottinen solu tuottaa eritettäviä (sekretorisia) proteiinilajejaan ja tehokkaana tehtaana sillä on kyky säädellä tuotantoaan- laajentaa tai supistaa , riippuen sen palvelujen vaatimuksista.
Endoplasmisen verkoston päätehtävä on koordinoida laadunkontrolliprosessi (ERQC prosessi), kun ne saapuvat sekretorisessa tiessään tähän laskostustehtaaseen. (Laskostamisessa syntyy perusteita proteiinin trimmatulle sekundääriselle ja korkemman asteen hahmolle ja täten funktionaalisesti merkitsevälle rakenteelle, ennen kuin se lähtetään ulos solukoneesta ja solusta).
- The Endoplasmic Reticulum (ER) is the major site for secretory protein production in eukaryotic cells and like an efficient factory, it has the capacity to expand or contract its output depending on the demand for its services. A primary function of the ER is to co-ordinate the quality control of proteins as they enter this folding factory at the base of the secretory pathway.
(Suom) Reduktio ja oksidaatiofraktioilla on tärkeä tehtävänsä laadunkontrolliprosessissa, koska se voi tarjota niitä disulfidisiltoja ja koska se pitää yllä suotuisaa redoxmiljöötä oksidatiiviselle proteiinien laskostamiselle. (vertauskuvallisesti voisi sanoa, että laskostamaton peptidirakenne on kuin pitkää lankaa, mutta laskostettu on kuin langasta virkattu "pitsiliina", jolla on jokin funktio. ERAD on järjestelmä joka purkaa väärän mallin ja hyödyntää jätematerian tavalla tai toisella. ERQC koettaa välillä purkaa ja sitten yrittää uudestaan ( lektiinisyklien avulla) oikeaa mallia ja taas purkaa ja taas yrittää ja jos onnistuu saamaan oikean mallin, " pitsiliina pääsee tehtaasta ulos tehtäviinsä joutumatta ERAD hampaisiin. SARS virus aikoo päästä tästä järjstelmästä ulos joutumatta ERAD- hampaisiin ja saamalla kuitenkin hyvän laskostuksen)
- Reduction–oxidation (redox) reactions have an important role to play in the quality control process, through the provision of disulphide bonds and by maintaining a favourable redox environment for oxidative protein folding.
(Suom) Endoplasminen retikulum osallistuu myös kalsiumin homeostaasiin ja se on pääpaikka lipidien biosynteesille. Nämä molemmat prosessit vaikuttuvat myös ER. aition redox-tilanteesta.
- The ER is also a major contributor to calcium homeostasis and is a key site for lipid biosynthesis, two processes that additionally impact upon, and are influenced by, redox in the ER compartment.
ERP44 , (9q31.1), https://www.ncbi.nlm.nih.gov/gene/23071
Also known as PDIA10; TXNDC4. Summary. This gene encodes a member of the protein disulfide
isomerase (PDI) family of endoplasmic reticulum (ER) proteins. It has an
inferred N-terminal signal peptide, a catalytically active thioredoxin
(TRX) domain, two TRX-like domains and a C-terminal ER-retention
sequence. This protein functions as a pH-regulated chaperone of the
secretory pathway and likely plays a role in protein quality control at
the endoplasmic reticulum - Golgi interface. [provided by RefSeq, Dec
2016] Expression. Ubiquitous expression in thyroid (RPKM 19.6), placenta (RPKM 16.9) and 25 other tissues See more
Zinc regulates ERp44-dependent protein quality control in the early secretory pathway.
Watanabe S, et al. Nat Commun, 2019 Feb 5. PMID 30723194, Free PMC Article
- Conserved Domains (3) summary
-
- cd02996
Location:29 → 136 - PDI_a_ERp44; PDIa family, endoplasmic reticulum protein 44 (ERp44) subfamily; ERp44 is an ER-resident protein, induced during stress, involved in thiol-mediated ER retention. It contains an N-terminal TRX domain, similar to that of PDIa, with a CXFS motif followed by two redox inactive TRX-like domains, homologous to the b and b' domains of PDI. Through the formation of reversible mixed disulfides, ERp44 mediates the ER localization of Ero1alpha, a protein that oxidizes protein disulfide isomerases into their active form. ERp44 also prevents the secretion of unassembled cargo protein with unpaired cysteines. ERp44 also modulates the activity of inositol 1,4,5-triphosphate type I receptor (IP3R1), an intracellular channel protein that mediates calcium release from the ER to the cytosol. Similar to PDI, the b domain of ERp44 is likely involved in binding to substrates.
- cd03070
Location:144 → 234 - PDI_b_ERp44; PDIb family, ERp44 subfamily, first redox inactive TRX-like domain b; ERp44 is an endoplasmic reticulum (ER)-resident protein, induced during stress, involved in thiol-mediated ER retention. It contains an N-terminal TRX domain with a CXFS motif followed ...
- cd03072
Location:245 → 355 - PDI_b'_ERp44; PDIb' family, ERp44 subfamily, second redox inactive TRX-like domain b'; ERp44 is an endoplasmic reticulum (ER)-resident protein, induced during stress, involved in thiol-mediated ER retention. It contains an N-terminal TRX domain with a CXFS motif ...
- cd02996
ORIGIN 1 mhpavflslp dlrcsllllv twvftpvtte itsldtenid eilnnadval vnfyadwcrf 61 sqmlhpifee asdvikeefp nenqvvfarv dcdqhsdiaq ryriskyptl klfrngmmmk 121 reyrgqrsvk aladyirqqk sdpiqeirdl aeittldrsk rniigyfeqk dsdnyrvfer 181 vanilhddca flsafgdvsk perysgdnii ykppghsapd mvylgamtnf dvtynwiqdk 241 cvplvreitf engeelteeg lpflilfhmk edtesleifq nevarqlise kgtinflhad 301 cdkfrhpllh iqktpadcpv iaidsfrhmy vfgdfkdvli pgklkqfvfd lhsgklhref 361 hhgpdptdta pgeqaqdvas sppessfqkl apseyrytll rdrdel //
GENE CARDS;
Endoplasmic Reticulum Protein 44
2
3
5
, Thioredoxin Domain Containing 4 (Endoplasmic Reticulum)
2
3
, Protein Disulfide Isomerase Family A, Member 10
2
3
Endoplasmic Reticulum Resident Protein 44 3 4 , Thioredoxin Domain-Containing Protein 4 3 4
ER Protein 44 3 4 , TXNDC4 3 4 , Endoplasmic Reticulum Resident Protein 44 KDa 3
Epididymis Secretory Sperm Binding Protein 3 , KIAA0573 4
PDIA10 3 , ERP44 Gene
Endoplasmic Reticulum Resident Protein 44 3 4 , Thioredoxin Domain-Containing Protein 4 3 4
ER Protein 44 3 4 , TXNDC4 3 4 , Endoplasmic Reticulum Resident Protein 44 KDa 3
Epididymis Secretory Sperm Binding Protein 3 , KIAA0573 4
PDIA10 3 , ERP44 Gene
ERP44 (Endoplasmic Reticulum Protein 44) is a Protein Coding gene.
Diseases associated with ERP44 include Multiple Sulfatase Deficiency and Heavy Chain Disease.
Among its related pathways are Innate Immune System and Translational Control.
Gene Ontology (GO) annotations related to this gene include calcium ion binding and protein disulfide isomerase activity.
An important paralog of this gene is PDIA4.
Mediates thiol-dependent retention in the
early secretory pathway, forming mixed disulfides with substrate
proteins through its conserved CRFS motif. Inhibits the calcium channel
activity of ITPR1. May have a role in the control of oxidative protein
folding in the endoplasmic reticulum. Required to retain ERO1A and ERO1B
in the endoplasmic reticulum. ERP44_HUMAN,Q9BS2
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