ER -alfaglukosidaasi-inhibiittoreista 2019 llä koetetaan jarruttaa viruksen N-glykosylaation hankkimista.

https://pubmed.ncbi.nlm.nih.gov/30976784/#&gid=article-figures&pid=fig-1-uid-0SARS-2 


Interaktioproteiineja N-glykosylaatioprosessissa:
https://www.genecards.org/cgi-bin/carddisp.pl?gene=MOGS&keywords=MOGS,CDG2B
 https://ars.els-cdn.com/content/image/1-s2.0-S016635421300168X-gr1.jpg

Aliases for MOGS Gene

• Mannosyl-Oligosaccharide Glucosidase ^{2 3 4 5}
• Processing A-Glucosidase I ^{2 3 4}
• Glucosidase I ^{2 3}
• EC 3.2.1.106 ^{4 52}
• GCS1 ^{3 4}
• Epididymis Secretory Sperm Binding Protein ³
• CDG2B ³
• CWH41 ³
• DER7 ³

Entrez Gene Summary for MOGS Gene

• This gene encodes the first enzyme in the N-linked oligosaccharide processing pathway. The enzyme cleaves the distal alpha-1,2-linked glucose residue from the Glc(3)-Man(9)-GlcNAc(2) oligosaccharide precursor. This protein is located in the lumen of the endoplasmic reticulum. Defects in this gene are a cause of type IIb congenital disorder of glycosylation (CDGIIb). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
   GeneCards Summary for MOGS Gene 
• MOGS (Mannosyl-Oligosaccharide Glucosidase) is a Protein Coding gene. Diseases associated with MOGS include Congenital Disorder Of Glycosylation, Type Iib and Synchronous Multifocal Osteogenic Sarcoma. Among its related pathways are Metabolism of proteins and Transport to the Golgi and subsequent modification. Gene Ontology (GO) annotations related to this gene include mannosyl-oligosaccharide glucosidase activity and glucosidase activity.UniProtKB/Swiss-Prot Summary for MOGS Gene
• Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor in a highly specific manner.
  • MOGS_HUMAN,Q13724

  Htm1 protein generates the N-glycan signal for glycoprotein degradation in the endoplasmic reticulum. (PMID: 19124653)
  

  Abstract:
  

  To maintain protein homeostasis in secretory compartments...are essential in glycoprotein ERAD; the covalent oligosaccharide structure is used as a signal to display the folding...exomannosidase that generates the Man(7)GlcNAc(2) oligosaccharide with a terminal alpha1,6-linked mannosyl residue on degradation substrates. This oligosaccharide signal is decoded by the ER-localized lectin Yos9p...exomannosidase activity requires processing of the N-glycan by glucosidase I, glucosidaseII, and mannosidase I, resulting in a sequential order...

  Mesh Term:
  

  Oligosaccharides

  
  
  MOGS mannosyl oligosakkaridi- glukosidaasia on SARS-2 viruksen nsp7  proteiinin  interaktioproteiini.
  SARS2   nsp7 ei vaikuta  hankkivan itse glykosylaatiota ja sen rakenne on vajaata valkuaista, siitä puuttuu P ja Y ja  sillä on tumaan kuljettava motiivi.
  N-glykosylaation aikana esiintyvä proteiini UGGT2 on myös SARS2- viruksen ORF8:n interaktioproteiini UDP-glukoosi gp glykosyylitransferaasi 2. ja toimii ERQC:ssä CLR/CNX syklin  ohessa.  Spike proteiini välttää kalretikuliinia.
  Calnexiini on Spikeproteiinin interaktiossa  siten että spike saa glykosylaation ja laskostuksensa ja läpäiseen  ERQC kontrollin.  
  
  

  •  https://www.genecards.org/cgi-bin/carddisp.pl?gene=UGGT2&keywords=UGGT2

  
  Muita interaktioproteiineja tässä yhteydessä on vielä ERLEC1. Kirjoitan seuraavan otsikon alle.