ECDC linkki:: Sars-CoV-2 Variants of Interest (VOI) and Variants under Monitoring (VUM) . 8th September 2022

https://www.ecdc.europa.eu/en/covid-19/variants-concern

Variants of Interest (VOI)

For these variants, evidence is available on genomic properties, epidemiological evidence or in-vitro evidence that could imply a significant impact on transmissibility, severity and/or immunity, realistically having an impact on the epidemiological situation in the EU/EEA. However, the evidence is still preliminary or is associated with major uncertainty. In addition, all the criteria for variants under monitoring outlined below apply.

WHO label	Lineage + additional mutations	Country first detected (community)	Spike mutations of interest	Year and month first detected	Impact on transmissibility	Impact on immunity	Impact on severity	Transmission in EU/EEA
Omicron	BA.2 + L452X (x)	n/a	L452X	n/a	No evidence	Increased (7)	No evidence	Detected (a)
Omicron	BA.2.75	India	(y)	May 2022	No evidence	Increased (9, 10)	No evidence	Detected (a)

 

x: Any amino-acid substitution

y: W152R, F157L, I210V, G257S, D339H, G446S, N460K, Q493 (reversion)

Variants under monitoring (VUM)

These additional variants of SARS-CoV-2 have been detected as signals through epidemic intelligence, rules-based genomic variant screening, or preliminary scientific evidence. There is some indication that they could have properties similar to those of a VOC, but the evidence is weak or has not yet been assessed by ECDC. Variants listed here must be present in at least one outbreak, detected in a community within the EU/EEA, or there must be evidence that there is community transmission of the variant elsewhere in the world.

WHO label	Lineage + additional mutations	Country first detected (community)	Spike mutations of interest	Year and month first detected	Impact on transmissibility	Impact on immunity	Impact on severity	Transmission in EU/EEA
Omicron	XAK	Germany	(y)	June 2022	No evidence	No evidence	No evidence	Detected (a)
Omicron	BA.4 + R346X (x)	n/a	R346X	n/a	No evidence	No evidence	No evidence	Detected (a)
Omicron	BA.5 + R346X (x)	n/a	R346X	n/a	No evidence	No evidence	No evidence	Detected (a)

 

x: Any amino-acid substitution

y: K147E, N460K, G339D, Δ69