https://www.ecdc.europa.eu/en/covid-19/variants-concern
Changes
to list of SARS-CoV-2 variants
of
concern, variants of interest, and
variants
under
monitoring
ECDC
reviews the variants list at least weekly and if changes are
indicated, these are detailed here. When notlisted, it
indicates
that the weekly review did not result in any changes.
25
August
2022
•
Added
BA.4 +
R346X as
a variant under
monitoring
• Added
BA.5 + R346X as a
variant
under monitoring
11
August 2022
•
Changed
classification of BA.1 (Omicron) from VOC to De-escalated variant
•
Changed
classification of BA.3 (Omicron) from VUM to De-escalated variant
•
Added
references for severity for
BA.5
• Added
references for immunity for BA.2.75
28
July 2022
• Added
recombinant
XAK as
a variant under monitoring
14
July 2022
• Re-classified
BA.2.75
from a
variant under monitoring to
a variant of interest
7
July 2022
• Added
BA.2.75
as a
variant under
monitoring
9
June 2022
• Changed
classification of B.1.617.2
(Delta)
from
VOC
to
De-escalated variant
• Changed
classification of BA.2
+ L452X from
VUM to VOI
• Changed
the transmission status of BA.4 and BA.5 from sporadic/travel to
community
12
May 2022
• Changed
classification of Omicron
sub-lineages BA.4 and BA.5 from VOI
to
VOC
•
Added
spike mutation of interest R493Q
for
BA.4 and BA.5
5
May 2022
• Changed
classification of XD
from VUM
to
De-escalated variants
• References
were added for immunity of BA.4,
BA.5 and BA.2+L452X
21
April 2022
• Added
BA.2 +
L452X as
a variant under monitoring
7
April 2022
• The
major sub-lineages of Omicron (currently BA.1, BA.2, BA.3, BA.4 and
BA.5) are monitored
separately
•
References
of
studies of Omicron where the sub-lineage
could not be identified were removed
•
References
were added for transmissibility of BA.1
•
References
were added for severity of BA.2
• Omicron
sub-lineages BA.1 and BA.2 remains as variants
of
concern
•
Omicron
sub-lineage BA.3 was classified as a
variant
under monitoring
• Omicron
sub-lineages BA.4 and BA.5 was added
to the list of variants
of
interest
•
Changed
classification of recombinant
XF from VUM to
De-escalated variant
31
March 2022
• Changed
classification of B.1.351 (Beta)
and
P.1 (Gamma)
from
VOCs
to
De-escalated variants
• Changed
classification of B.1.640 from VUM to De-escalated variant.
11
March 2022
• Added
recombinant
AY.4 x BA.1 (XF)
as a
variant under monitoring
3
March
2022
•
Added
recombinant
AY.4.2.2 x BA.1.1 (XD)
as a
variant under monitoring
with
reference providing
genomic
characterization
17
February 2022
• Replaced
references
with 2 new references- for
Evidence impact on transmissibility for Omicron and
changed
assessment from
Unclear
to
Increased
(removed
footnote)
• Added
references
-for
Evidence impact on immunity
for
Omicron
• Replaced
references
with
new references -for
Evidence impact on immunity
for
Severity
and removed
the
footnote
• Changed
classification of B.1.621 (Mu), C.37 (Lambda) and AY.4.2 from VOI to
De-escalated
variants
• Changed
classification of B.1.1.318, B.1.617.2+K417N,
C.1.2, B.1.617.2+E484X, B.1.617.2+Q613H,
B.1.617.2+Q677H
from
VUM
to
De-escalated variants
• Since
VOI table is empty now, removed the table in the webpage
20
January
2022
• Changed
Transmission
in EU/EEA for
Omicron from
Community
to
Dominant.
•
Added
references
(5 references) for Evidence impact on severity for Omicron and
changed assessment
from
Unclear
to
Reduced
severity
•
Changed
footnotes for both Evidence on
transmission
and severity for Omicron
•
Changed
classification
of
C.36
+ L452R and P.1 + P681H
from
VUM to De-escalated variants
5
January 2022
• Changed
Transmission
in EU/EEA for
Delta from
Dominant
to
Community.
•
Added
references
for Evidence impact on transmissibility
and severity for Omicron
• Changed
category
annotations to increased,
reduced, similar, unclear, or no evidence
13
December 2021
• Changed
Transmission
in EU/EEA for
B.1.1.529 from
Sporadic/Travel
to
Community.
3
December 2021
• Added
reference
for
Evidence for impact on immunity for Omicron
26
November 2021
• Added
B.1.1.529
as a
variant of
concern
25
November 2021
• Added
B.1.1.529
as a
variant of
interest
11
November 2021
• Clarified
the Description
of the tables regarding
categories within a category
• Re-classified
AY.4.2 from a variant
under monitoring to
a variant of interest
• Added
B.1.640
as a
variant under monitoring
• Updated
the list of references
20
October 2021
• Added
B.1.617.2+
Q677H
as a
variant under monitoring
• Added
AY.4.2
as a
variant under monitoring
• Expanded
B.1.617.2+E484Q monitoring to include all amino acid substitutions of
position 484
8
October 2021
• Changed
classification of
B.1.620 from VOI to De-escalated variants
•
Changed
classification of AT.1 from VUM to De-escalated variants
3
September 2021
• Changed
classification of B.1.1.7 (Alpha)
and B.1.1.7+E484K from VOC to De-escalated
variants
• Changed
classification of variants B.1.525
(Eta), B.1.617.1 (Kappa), and P.3 (Theta) from VOI to De-
escalated
variants B.1.617.3, B.1.214.2, A.23.1+E484K, A.27, A.28, C.16,
B.1.351+P384L,
B.1.351+E516Q,
B.1.1.7+L452R, B.1.1.7+S494P, B.1.526, B.1.526.1 (lineage withdrawn
from Pango),
B.1.526.2
(lineage withdrawn from Pango), P.2, B.1.1.519, AV.1 from VUM to
De-escalated variants.
• Added
WHO naming to C.1.2 (Mu).
26
Aug 2021
• Added
B.1.617.2+E484Q
as a
variant under monitoring
• Added
B.1.617.2+Q613H
as a
variant under monitoring
• Added
clarification that listed lineages also include all sublineages
unless otherwise specified
• Added
links to the Pango lineage website, specific for each lineage.
29
July 2021
• Added
C.1.2 as a variant under monitoring
22
July 2021
• Changed
classification of C.37 (Lambda)
from VUM to VOI. Added references to
pre-print publications
for
evidence
of impact on immunity for C.37.
•
Added
a new category of variants (De-escalated variants)
•
Changed
classification of B.1.427/B.1.429
(Epsilon)
from VOI to De-escalated variants
• Changed
classification of B.1.616
from
VOI to De-escalated variants
24
June
2021
• Added
B.1.617.2+K417N as a variant under monitoring
18
June 2021
• Added
WHO naming to C.37 (Lambda)
•
Added
references on vaccine escape for B.1.617.2 (Delta)
03
June 2021
• Changed
classification of B.1.617.3 from VOI to the variant
under monitoring
(VUM)
category
•
P.1+P681H
added
to the variant
under monitoring
(VUM)
category
24
May 2021
• Changed
classification of B.1.617.2 from VOI to VOC
•
Added
reference to pre-print for evidence for
immunity for B.1.617.2
• Added
reference to UK technical briefing 12 to evidence for B.1.617.2
20
May 2021
• Mutations
affecting the S1 part of the spike protein S1/S2 junction domain
(residues 613-705) have
been
added to
the mutations of interest lists
for each variant. The
mutations of interest now include
changes
to spike
protein residues 319-541 and 613-705, and any additional unusual
changes specific to
the
variant.
• Changed
Transmission
in EU/EEA for
B.1.617.2 from
Sporadic/Outbreak
to
Community.
•
Added
reference to
Public Health England technical briefing 11 to
the evidence for increased
transmissibility
for B.1.617.2.
• Added
reference to pre-print publications for evidence of impact on
immunity for B.1.617.1.
• Added
B.1.1.519 (first detected in Mexico) and AV.1 (first detected in the
UK) to the monitoring
category.
11
May 2021
• Added
references to
Public
Health England technical briefings 9-10 to the
evidence for increased
transmissibility
for B.1.617.2.
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