Pohtimisen arvoinen K-vitamiinia vaativa geenituote Gas6, (Growth Arrest Specific gene 6) . Virus voi hyödyntää apoptoottista pintasignaaliaan päästäkseen soluun..

https://www.genecards.org/cgi-bin/carddisp.pl?gene=GAS6&keywords=Gas6 

13q34

• GeneCards Symbol: GAS6 ²
• Growth Arrest Specific 6 ^{2 3 5}
• AXL Receptor Tyrosine Kinase Ligand ^{2 3 4}
• AXLLG ^{3 4 5}
• AXSF ^{2 3 5}

• Growth Arrest-Specific Protein 6 ^{3 4}
• AXL Stimulatory Factor ^{2 3}
• DKFZp666G247 ^{2 5}
• FLJ34709 ^{2 5}
• GAS-6 ⁴

Entrez Gene Summary for GAS6 Gene

• This gene encodes a gamma-carboxyglutamic acid (Gla)-containing protein thought to be involved in the stimulation of cell proliferation. This gene is frequently overexpressed in many cancers and has been implicated as an adverse prognostic marker. Elevated protein levels are additionally associated with a variety of disease states, including venous thromboembolic disease, systemic lupus erythematosus, chronic renal failure, and preeclampsia. [provided by RefSeq, Aug 2014]

GAS6 (Growth Arrest Specific 6) is a Protein Coding gene. Diseases associated with GAS6 include Mesangial Proliferative Glomerulonephritis and Lupus Erythematosus. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and GPCR Pathway. Gene Ontology (GO) annotations related to this gene include calcium ion binding and voltage-gated calcium channel activity. An important paralog of this gene is MEGF6.

UniProtKB/Swiss-Prot Summary for GAS6 Gene

Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. ( GAS6_HUMAN,Q14393 )

(Microbial infection) Can bridge virus envelope phosphatidylserine to the TAM receptor tyrosine kinase Axl to mediate viral entry by apoptotic mimicry (PubMed:21501828). Plays a role in Dengue cell entry by apoptotic mimicry (PubMed:23084921). Plays a role in Vaccinia virus cell entry by apoptotic mimicry (PubMed:21501828). Plays a role in ebolavirus and marburgvirus cell entry by apoptotic mimicry (PubMed:17005688). ( GAS6_HUMAN,Q14393 )

https://www.researchgate.net/publication/345847351_Role_of_Vitamin_K-Dependent_Factors_Protein_S_and_GAS6_and_TAM_Receptors_in_SARS-CoV-2_Infection_and_COVID-19-Associated_Immunothrombosis