https://github.com/cov-lineages/pango-designation/issues/2018
"FL" Alias XBB.1.9.1
Esittelyteksteistä sitaatti:
Nimim. krosa:
FL.4 with Orf8:S67F #2018
Sublineage of FL.4
Mutations Added to FL.4: A28615G
(early)->C23635T(early)->A3948G(late)->C28093T(latest) The two
early silent mutation describes about 20% of FL.4 sequences. This
variant likely evolved from that.
Gisaid Inquiry: G5720A,G16741T,A3948G,C28093T
Find 311 good (complete, excluding low coverage) sequences: EPI_ISL_17016324,
This mutation is very interesting, it is major in Mu(B.1.621 and some contemporary larger VOCs (Delta and Alpha), and
during the BA.2.75* wave it appeared mostly within BR.2.1, but also gets
mentions in CH.1.1 sub-clades. Now it appear at a great quantity within
the FL.4* class, which is a quite large sub-lineage of the globally
successful XBB.1.9.1 family. Yet this seems preposterous because XBB.1*
usually discard most of their ORF8 protein by the ORF8:G8* mutation, and
this mutation actually stays in all 311 sequences I listed here.
Simply because it was a very important mutation and it has a sheer
number (few issues would have more than three hundreds sequences when
submitted) I want to monitor this within the main repository. If this
thing turned out to seem more than a silent mutation, then I consider it
to be a challenger to the theory that ORF8 protein doesn't matter any
more in XBB.
ryhisner I would like to ask you for more explanation about ORF8 protein evolution as you are obviously experienced with that.
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