GITHUB kertoo, että rekombinanttivarianttia XBB.2.3.3 löytyy lentokenttien tarkistuksissa eri puolilta maailmaa.Filippiineillä sitä on vallalla.

 https://github.com/cov-lineages/pango-designation/issues/2005

Uutisia ja pohdintoja tämän VUM-variantin variantin suhteen.

SITAATTI:

"XBB.2.3.3 with Orf8:E106Q and Orf1a:I4205V (40seqs) likely at high prevalence recently in Philippines and been caught in airport surveillance of multiple countries very recently. #2005"

 Nimim.F.G: kertoo 

"I was digging a bit in international sequences labelled as travel related with Philippines when i was hit by this tree: (USHER  map)

"It is self evident also at a first glance that Airport surveillance sequences are over-represented
And this become clearer searching on Gisaid the related query A12878G,A12878G, C19884T,A22108T
that finds 40 samples : 13 of them are selected inputing Airport and 4 more inputing Travel and 1 more inputing From

Interesting if the input is Philippines 5 out of these 18 of the international caught subgroup are found.

Interestingly if i set Philippines as free keyword on Gisaid querying for samples collected after May 1
i found that 3 out of 20 belong to this sublineage.

My guess is that this sublineage is likely one of the driver of the ongoing wave in Philippines or at least in a part of them.

Defining mutations:
XBB.2.3.3 >> > C19884T > Orf8:E106Q (G28209C) >Orf1a:I4205V (A12878G NSP9_I65V)

Sequences: 40 ( 33 of them collected after April 15)"

(Nextstrain map)

" Looking at the tree this sublineage clearly splitted in two main branches the first defined by Orf1b:V1110I and the bottom one by a mini saltation the infamous AY.4.2 mutation S:A222V plus N:R319H plus Orf1a:V1915I"

 Lisäkommentti eilen  Nimim "avic..."

It would be best if usher and cov-spectrum can display original country for travel-related seqs. There's limited formats so can be automated.

Currently there seems no way other than checking every single seq manually, which is very inconvenient."