Hepatiitti B viruksen ihmiskunnalle asettamiin ongelmiin kuuluu sen miltei tuntematon tapa tunkeutua maksasoluun ja voittaa luonnollisen immuunivasteen heti ehtivä puolustusvalli. Taudin tultua ilmi on jo kyse T soluvälitteisestä vasteesta ja taudin oireet tulevat tästä voimakkaasta myöhäisestä adaptatiivisien immuniteetin vasteesta. Siis alkuvaihe on näkymätön ja se pitäisi hahmottaa, koska siihen pitäisi ehtiä kehittää jokin puolustus. Otan nyt englantilaista tekstiä sitaatteina asian alustukseksi ja siten käännän uusinta väitöskirjaa.
Viruses 2010, 2(7), 1394-1410
Viruses 2010, 2(7), 1394-1410
Review
Innate Antiviral Immune Responses to Hepatitis B Virus
Malika Ait-goughoulte 1,2, Julie Lucifora Received: 4 June 2010, in revised form: 22 June 2010 / Accepted: 1 July 2010 / Published: 5 July 2010
Hepatitis B virus (HBV) is a major cause of acute and chronic hepatitis in humans. As HBV itself is currently viewed as a non-cytopathic virus, the liver pathology associated with hepatitis B is mainly thought to be due to immune responses directed against HBV antigens.
The outcome of HBV infection is the result of complex interactions between replicating HBV and the immune system. While the role of the adaptive immune response in the resolution of HBV infection is well understood, the contribution of innate immune mechanisms remains to be clearly defined.
The innate immune system represents the first line of defense against viral infection, but its role has been difficult to analyze in humans due to late diagnosis of HBV infection.
In this review, we discuss recent advances in the field of innate immunity to HBV infection.
Keywords: Hepatitis B virus; innate immunity; cytokines; pathogenesis
1. Introduction2. HBV, a stealth virus that does not elicit innate immunity?
3. Can HBV, as other viruses, be sensed by the immune system?
4. Can HBV inhibit type-I interferon pathways?
5. Can HBV inhibit host sensors of the innate response?
6. Concluding remarks
References
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