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onsdag 15 oktober 2014

TIM-1 sequence which can be used as an immunogen (Patents)

 http://www.google.com/patents/WO2013078089A1?cl=en
"Detailed Description
ARD5 is an exemplary monoclonal antibody  8MoAb) that specifically binds to human
TIM- 1 on the BED face of the protein at an epitope that includes the arginine amino acid residues at positions 85 and 86.
The anti-TIM-1 antibodies described herein inhibit TIM- 1 binding to phosphatidylserine and dendritic cells and can be used to treat or prevent immunological disorders such as inflammatory and autoimmune conditions.

TIM-1
The amino acid sequence of the human TIM-1 protein is shown as:
MHPQVVILSL ILHLADSVAG SVKVGGEAGP SVTLPCHYSG AVTSMCWRGS CSLFTCQNGI
VWTNGTHVT YRKDTRYKLL GDLSRRDVSL TIENTAVSDS GVYCCRVEHR GWFNDMKITV SLEIVPPKVT TTPIVTTVPT VTTVRTSTTV PTTTTVPMTT VPTTTVPTTM SIPTTTTVLT TMTVSTTTSV PTTTSIPTTT SVPVTTTVST FVPPMPLPRQ NHEPVATSPS SPQPAETHPT TLQGAIRREP TSSPLYSYTT DGNDTVTE SS DGLWNNQTQL FLEHSLLTAN TTKGIYAGVC ISVLVLLALL GVIIAKKYFF KKEVQQLSVS FSSLQIKALQ NAVEKEVQAE DNIYIENSLY
ATD (SEQ ID NO: 1).
This human TIM-1 protein can be used as an immunogen to prepare anti- human TIM-1 antibodies. Anti-human TIM-1 antibodies can then be screened to identify antibodies having the features described herein (e.g., binding at an epitope that includes arginine amino acid residues at positions 85 and 86 of TIM- 1)."

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