(PAMP) Tollin kaltaiset reseptorit ,ligandit sijainteineen, adaptorit sijainteineen, solutyypit (Kertausta!)

http://www.nature.com/onc/journal/v27/n2/fig_tab/1210906f1.html

Summary of known mammalian TLRs

http://en.wikipedia.org/wiki/Toll-like_receptor

Toll-like receptors bind and become activated by different ligands, which, in turn, are located on different types of organisms or structures. They also have different adapters to respond to activation and are located sometimes at the cell surface and sometimes to internal cell compartments. Furthermore, they are expressed by different types of leucocytes or other cell types:

Receptor	Ligand(s)[27]	Ligand location[27]	Adapter(s)	Location	Cell types[27]
TLR 1	multiple triacyl lipopeptides	Bacteria	MyD88/MAL	cell surface	monocytes/macrophages a subset of dendritic cells B lymphocytes
TLR 2	multiple glycolipids	Bacteria	MyD88/MAL	cell surface	monocytes/macrophages neutrophils [28] Myeloid dendritic cells[29] Mast cells
	multiple lipopeptides	Bacteria
	multiple lipoproteins	Bacteria
	lipoteichoic acid	Gram-positive bacteria
	HSP70	Host cells
	zymosan (Beta-glucan)	Fungi
	Numerous others
TLR 3	double-stranded RNA, poly I:C	viruses	TRIF	cell compartment	Dendritic cells B lymphocytes
TLR 4	lipopolysaccharide	Gram-negative bacteria	MyD88/MAL/TRIF/TRAM	cell surface	monocytes/macrophages neutrophils [28] Myeloid dendritic cells[29] Mast cells B lymphocytes [30] Intestinal epithelium
	several heat shock proteins	Bacteria and host cells
	fibrinogen	host cells
	heparan sulfate fragments	host cells
	hyaluronic acid fragments	host cells
	nickel
	Various opioid drugs
TLR 5	flagellin	Bacteria	rowspan=2| MyD88	cell surface	monocyte/macrophages a subset of dendritic cells Intestinal epithelium
	[[profilin[31]]]	Toxoplasma gondii
TLR 6	multiple diacyl lipopeptides	Mycoplasma	MyD88/MAL	cell surface	monocytes/macrophages Mast cells B lymphocytes
TLR 7	imidazoquinoline	small synthetic compounds	MyD88	cell compartment	monocytes/macrophages Plasmacytoid dendritic cells[29] B lymphocytes
	loxoribine (a guanosine analogue)
	bropirimine
	single-stranded RNA	RNA viruses
TLR 8	small synthetic compounds; single-stranded RNA		MyD88	cell compartment	monocytes/macrophages a subset of dendritic cells Mast cells
TLR 9	unmethylated CpG Oligodeoxynucleotide DNA	Bacteria, DNA viruses	MyD88	cell compartment	monocytes/macrophages Plasmacytoid dendritic cells[29] B lymphocytes
TLR 10	unknown		unknown	?
TLR 11	Profilin	Toxoplasma gondii[32]	MyD88	cell compartment[33]	monocytes/macrophages liver cells kidney urinary bladder epithelium
TLR 12	Profilin	Toxoplasma gondii[34]	MyD88		Neurons[35] plasmacytoid dendritic cells conventional dendritic cells macrophages
TLR 13 [36][37]	bacterial ribosomal RNA sequence “CGGAAAGACC”	Virus, bacteria	MyD88, TAK-1	cell compartment	monocytes/macrophages conventional dendritic cells