Emerg Infect Dis. 2014 Oct;20(10). doi: 10.3201/eid2010.140430.
Biomarker correlates of survival in pediatric patients with ebola virus disease.
Abstract
Outbreaks of Ebola virus
disease (EVD) occur sporadically in Africa and are associated with high
case-fatality rates. Historically, children have been less affected
than adults. The 2000-2001 Sudan virus-associated
EVD outbreak in the Gulu district of Uganda resulted in 55 pediatric
and 161 adult laboratory-confirmed cases. We used a series of multiplex
assays to measure the concentrations of 55 serum analytes in specimens
from patients from that outbreak to identify biomarkers specific to
pediatric disease. Pediatric patients who survived had higher levels of
the chemokine regulated on activation, normal T-cell expressed and
secreted marker and lower levels of plasminogen activator inhibitor 1,
soluble intracellular adhesion molecule, and soluble vascular cell
adhesion molecule than did pediatric patients who died. Adult patients
had similar levels of these analytes regardless of outcome. Our findings
suggest that children with EVD may benefit from different treatment regimens than those for adults.
Inga kommentarer:
Skicka en kommentar