Expert Rev Anti Infect Ther. 2013 May;11(5):475-8. doi: 10.1586/eri.13.30.
Abstract
Ebola
viruses encode two glycoproteins (GPs): a membrane-associated GP that
is present in the viral membrane and mediates viral attachment and entry
into host cells; and a secreted, nonstructural glycoprotein (sGP)
that is identical to GP over approximately 90% of its length. A recent
study by Mohan and colleagues attributes a novel immune evasion
mechanism dubbed 'antigenic subversion' to sGP. Using DNA immunization in mice, the authors demonstrate that sGP elicits antibodies that crossreact with GP, but these antibodies are non-neutralizing. Coimmunization with sGP plus GP or sequential immunizations with GP and sGP direct the host antibody response toward non-neutralizing epitopes. Therefore, the production of sGP may prevent effective neutralization of the virus during Ebola virus infection, and may reduce the effectiveness of vaccines that rely upon neutralizing antibody responses.
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