Viimeisiä kliinisiä uutisia PubMed lähteestä omikronvarianteista : 10 sitaattia englanniksi

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Emergence of Omicron sub-variant BA.2: Is it a matter of concern amid the COVID-19 pandemic?

Dhawan M, et al. Int J Surg. 2022. PMID: 35202859 Free PMC article. No abstract available.

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Omicron: What Makes the Latest SARS-CoV-2 Variant of Concern So Concerning?

Jung C, Kmiec D, Koepke L, Zech F, Jacob T, Sparrer KMJ, Kirchhoff F. J Virol. 2022 Mar 23;96(6):e0207721. doi: 10.1128/jvi.02077-21. Epub 2022 Mar 23. PMID: 35225672 Free PMC article. Review.

Emerging strains of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of the coronavirus disease 2019 (COVID-19) pandemic, that show increased transmission fitness and/or immune evasion are classified as "variants of con …

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Emergence of Omicron sub-variant BA.2: Is it a matter of concern amid the COVID-19 pandemic?

Dhawan M, Priyanka, Choudhary OP. Int J Surg. 2022 Mar;99:106581. doi: 10.1016/j.ijsu.2022.106581. Epub 2022 Feb 21. PMID: 35202859 Free PMC article. No abstract available.

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Neutralization of SARS-CoV-2 Omicron sub-lineages BA.1, BA.1.1, and BA.2.

Evans JP, Zeng C, Qu P, Faraone J, Zheng YM, Carlin C, Bednash JS, Zhou T, Lozanski G, Mallampalli R, Saif LJ, Oltz EM, Mohler PJ, Xu K, Gumina RJ, Liu SL. Cell Host Microbe. 2022 Apr 25:S1931-3128(22)00220-7. doi: 10.1016/j.chom.2022.04.014. Online ahead of print. PMID: 35526534 Free PMC article.

Recent reports of SARS-CoV-2 Omicron variant sub-lineages, BA.1, BA.1.1, and BA.2, have reignited concern over potential escape from vaccine- and infection-induced immunity. ...Critically, all Omicron sub-lineages, including …

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Tracking SARS-CoV-2 Omicron diverse spike gene mutations identifies multiple inter-variant recombination events.

Ou J, Lan W, Wu X, Zhao T, Duan B, Yang P, Ren Y, Quan L, Zhao W, Seto D, Chodosh J, Luo Z, Wu J, Zhang Q. Signal Transduct Target Ther. 2022 Apr 26;7(1):138. doi: 10.1038/s41392-022-00992-2. PMID: 35474215 Free PMC article.

The current pandemic of COVID-19 is fueled by more infectious emergent Omicron variants. ...There are three more Alpha-related mutations in BA.1 than BA.2, and BA.1 is phylogenetically closer to Alpha than other variants. .. …

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Molecular detection of SARS-CoV-2 and differentiation of Omicron and Delta variant strains.

Tsui WNT, Hamill V, Noll L, Lu N, Porter EP, Harbidge D, Cox E, Richardson C, Gray M, Sebhatu T, Goerl K, Brown S, Hanzlicek G, Retallick J, Bai J. Transbound Emerg Dis. 2022 Feb 26. doi: 10.1111/tbed.14497. Online ahead of print. PMID: 35218683

A new molecular assay that can detect and differentiate both the Delta and Omicron variants was developed. A collection of 660,035 SARS-CoV-2 full- or near-full genomes, including 169,454 Delta variant and 24,202 Omicron variant strains, …

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A fourth dose of Omicron RBD vaccine enhances broad neutralization against SARS-CoV-2 variants including BA.1 and BA.2 in vaccinated mice.

Zhou B, Song S, Guo H, Zhou X, Fan Q, Liu W, Cheng L, Ge X, Ju B, Zhang Z. J Med Virol. 2022 Apr 26:10.1002/jmv.27811. doi: 10.1002/jmv.27811. Online ahead of print. PMID: 35474319 Free PMC article.

However, a newly emerging Omicron variant, including BA.1, BA.1.1, BA.2, and BA.3 sublineages, largely escaped the neutralization of existing neutralizing antibodies (nAbs), even those elicited by three doses of vaccines. Here, we …

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Is Omicron the end of pandemic or start of a new innings?

Das S, Samanta S, Banerjee J, Pal A, Giri B, Kar SS, Dash SK. Travel Med Infect Dis. 2022 Apr 23;48:102332. doi: 10.1016/j.tmaid.2022.102332. Online ahead of print. PMID: 35472451 Free PMC article. Review.

In the middle of November 2021, Omicron (B.1.1.529), a novel variant of SARS-CoV-2 was identified in South Africa. Owing to continuous increasing cases with rapid transmissibility and immune evasion, the World Health Organization (WHO) has categorized this st …

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Signals of Significantly Increased Vaccine Breakthrough, Decreased Hospitalization Rates, and Less Severe Disease in Patients with Coronavirus Disease 2019 Caused by the Omicron Variant of Severe Acute Respiratory Syndrome Coronavirus 2 in Houston, Texas.

Christensen PA, Olsen RJ, Long SW, Snehal R, Davis JJ, Ojeda Saavedra M, Reppond K, Shyer MN, Cambric J, Gadd R, Thakur RM, Batajoo A, Mangham R, Pena S, Trinh T, Kinskey JC, Williams G, Olson R, Gollihar J, Musser JM. Am J Pathol. 2022 Apr;192(4):642-652. doi: 10.1016/j.ajpath.2022.01.007. Epub 2022 Feb 3. PMID: 35123975 Free PMC article.

Genetic variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continue to dramatically alter the landscape of the coronavirus disease 2019 (COVID-19) pandemic. ...Two patients with Omicron stealth sublineage BA.2 …

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COVID-19 Genetic Variants and Their Potential Impact in Vaccine Development.

Vo GV, Bagyinszky E, An SSA. Microorganisms. 2022 Mar 10;10(3):598. doi: 10.3390/microorganisms10030598. PMID: 35336173 Free PMC article. Review.

In the two years since the SARS-CoV-2 pandemic started, it has caused over 5 million deaths and 400 million infected cases, and the world continues to be on high alert for COVID-19. Among the variants of interest and concern of SARS-CoV-2, the current …

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Generalized Methodology for the Quick Prediction of Variant SARS-CoV-2 Spike Protein Binding Affinities with Human Angiotensin-Converting Enzyme II.

Williams AH, Zhan CG. J Phys Chem B. 2022 Mar 31;126(12):2353-2360. doi: 10.1021/acs.jpcb.1c10718. Epub 2022 Mar 22. PMID: 35315274 Free PMC article.

Variants of the SARS-CoV-2 virus continue to remain a threat 2 years from the beginning of the pandemic. ...From this methodology, we predicted that the Omicron variant spike has a K(d) of 22.69 nM (which is very close to the experimental