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Monkeypox Virus in Nigeria: Infection Biology, Epidemiology, and Evolution.
Viruses. 2020 Nov 5;12(11):1257. doi: 10.3390/v12111257.
PMID: 33167496
Free PMC article.
Review.
Monkeypox is a zoonotic disease caused by monkeypox virus
(MPXV), which is a member of orthopoxvirus genus. The reemergence of
MPXV in 2017 (at Bayelsa state) after 39 years of no reported case in
Nigeria, and the export of travelers' monkeypox (MPX) f …
Identification and Whole-Genome Sequencing of a Monkeypox Virus Strain Isolated in Israel.
Microbiol Resour Announc. 2020 Mar 5;9(10):e01524-19. doi: 10.1128/MRA.01524-19.
PMID: 32139560
Free PMC article.
We report the whole-genome sequence of a monkeypox virus strain isolated in Israel. The strain was isolated in 2018 from a patient travelling back from West Africa. The virus was fully sequenced on the Illumina MiSeq and Oxford Nanopore Technologies Mi …
2.1. Camelpox virus (CMLV) :https://journals.asm.org/doi/10.1128/MRA.00671-19
Genome Sequences of Akhmeta Virus, an Early Divergent Old World Orthopoxvirus.
Viruses. 2018 May 12;10(5):252. doi: 10.3390/v10050252.
PMID: 29757202
Free PMC article.
Annotated whole genome sequences of three isolates of the Akhmeta virus
(AKMV), a novel species of orthopoxvirus (OPXV), isolated from the
Akhmeta and Vani regions of the country Georgia, are presented and
discussed. The AKMV genome is similar in genomic …
Genomic history of human monkey pox infections in the Central African Republic between 2001 and 2018.
Sci Rep. 2021 Jun 22;11(1):13085. doi: 10.1038/s41598-021-92315-8.
PMID: 34158533
Free PMC article.
Monkeypox is an emerging infectious
disease, which has a clinical presentation similar to smallpox. In the
two past decades, Central Africa has seen an increase in the frequency
of cases, with many monkeypox virus (MPXV) isolates detected in the Democratic Re …
Figure 2
Phylogeny of monkeypox viruses
(MPXV) based on complete genomes. The Bayesian tree was reconstructed
using the GTR+G model. The two sequences used as outgroup are not shown.
For each MPXV sequence, we indicated the accession number in GenBank,
the geographic locality, the country, the code, and the year. The 10
MPXV genomes specially sequenced for this study are written in red.
Branches with an asterisk were supported by maximal Bayesian posterior
probability (PP = 1) and ML bootstrap proportions ≥ 95. The main clades
were highlighted with different colours: West African clade (orange),
Central African group I (blue), II (white), III (yellow), IV (green) and
V (pink). For convenience, the size of longest branches shown in grey
was reduced by five.
Zoonotic poxviruses.
Vet Microbiol. 2010 Jan 27;140(3-4):229-36. doi: 10.1016/j.vetmic.2009.08.026. Epub 2009 Aug 26.
PMID: 19828265
Review.
During the last two decades, reports on emerging human monkeypox outbreaks in Africa and North America, the increasing number of cowpox virus infections in cats, exotic animals and humans and cases of vaccinia virus infections in humans in South America and I …
Poxvirus tropism.
Nat Rev Microbiol. 2005 Mar;3(3):201-13. doi: 10.1038/nrmicro1099.
PMID: 15738948
Free PMC article.
Review.
Despite the success of the WHO-led smallpox eradication
programme a quarter of a century ago, there remains considerable fear
that variola virus, or other related pathogenic poxviruses such as monkeypox, could re-emerge and spread disease in the human population. .. …Poxvirus tropism at the cellular level seems to be regulated by
intracellular events downstream of virus binding and entry, rather than
at the level of specific host receptors as is the case for many other
viruses. This review summarizes our current understanding of poxvirus
tropism and host range, and discusses the prospects of exploiting
host-restricted poxvirus vectors for vaccines, gene therapy or
tissue-targeted oncolytic viral therapies for the treatment of human
cancers.
[Human monkeypox].
Pathol Biol (Paris). 2009 Mar;57(2):175-83. doi: 10.1016/j.patbio.2008.02.006. Epub 2008 Apr 3.
PMID: 18394820
Review.
French.
Unlike other recent viral emergences, which were in majority caused by RNA viruses, the monkeypox results from infection by a DNA virus, an orthopoxvirus (OPX) closely related to both vaccine and smallpox viruses and whose two genomic variants are known. ...This po …
Monkeypox virus and insights into its immunomodulatory proteins.
Immunol Rev. 2008 Oct;225:96-113. doi: 10.1111/j.1600-065X.2008.00691.x.
PMID: 18837778
Free PMC article.
Review.
However, in 2003, there was an outbreak in the United States, representing the first documented monkeypox cases in the Western hemisphere. Although monkeypox virus (MPXV) is less fatal and not as transmissible as variola virus, the causative agent of smallpox …
A Genome-Wide Haploid Genetic Screen Identifies
Heparan Sulfate-Associated Genes and the Macropinocytosis Modulator
TMED10 as Factors Supporting Vaccinia Virus (VAXV) Infection.
J Virol. 2019 Jun 14;93(13):e02160-18. doi: 10.1128/JVI.02160-18. Print 2019 Jul 1.
PMID: 30996093
Free PMC article.
We employed a genome-wide insertional mutagenesis approach in human haploid cells to identify host factors crucial for vaccinia virus infection. ...A number of these viruses are clinically important to humans, including variola virus (smallpox) and vaccinia …
Viruses. 2018 Oct 6;10(10):546. doi: 10.3390/v10100546.
PMID: 30301229
Free PMC article.
Phylogenetic analysis based on 102 conserved OPV genes
(core gene set) showed that OPV Abatino is most closely related to the
Ectromelia virus species (ECTV), although placed on a separate
branch of the phylogenetic tree, bringing substantial support to the
hypothesis that …
Orthopoxviruses (OPVs) are diffused over the complete Eurasian
continent, but previously described strains are mostly from northern
Europe, and few infections have been reported from Italy. Here we
present the extended genomic characterization of OPV Abatino, a novel
OPV isolated in Italy from an infected Tonkean macaque, with zoonotic
potential. Phylogenetic analysis based on 102 conserved OPV genes
(core gene set) showed that OPV Abatino is most closely related to the
Ectromelia virus species (ECTV), although placed on a separate branch of
the phylogenetic tree, bringing substantial support to the hypothesis
that this strain may be part of a novel OPV clade. Extending the
analysis to the entire set of genes (coding sequences, CDS) further
substantiated this hypothesis. In fact the genome of OPV Abatino
included more CDS than ECTV; most of the extra genes (mainly located in
the terminal genome regions), showed the highest similarity with cowpox
virus (CPXV); however vaccinia virus (VACV) and monkeypox virus (MPXV)
were the closest OPV for certain CDS. These findings suggest that OPV
Abatino could be the result of complex evolutionary events, diverging
from any other previously described OPV, and may indicate that
previously reported cases in Italy could represent the tip of the
iceberg yet to be explored.
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