Sars-2 VOC-varianttien kasvunopeuksien vertailusta Englannissa

 https://outbreak.info/resources/2022.02.02.22270110

 

 

Publication Preprint Spatial Growth Rate of Emerging SARS-CoV-2 Lineages in England, September 2020-December 2021 Matthew R Smallman-Raynor, Andrew D Cliff, and - The COVID-19 Genomics UK (COG-UK) Consortium view affiliations medRxiv published 02 February 2022 • accessed 08 February 2022 Record provided by medRxivdata.curatedBy.nameLearn more 

This paper uses a robust method of spatial epidemiological analysis to assess the spatial growth rate of multiple lineages of SARS-CoV-2 in the local authority areas of England, September 2020-December 2021. Using the genomic surveillance records of the COVID-19 Genomics UK (COG-UK) Consortium, the analysis identifies a substantial (7.6-fold) difference in the average rate of spatial growth of 37 sample lineages, from the slowest (Delta AY.4.3) to the fastest (Omicron BA.1). Spatial growth of the Omicron (B.1.1.529 and BA) variant was found to be 2.81x faster than the Delta (B.1.617.2 and AY) variant and 3.76x faster than the Alpha (B.1.1.7 and Q) variant.

 In addition to AY.4.2 (a designated variant under investigation, VUI-21OCT-01), three Delta sublineages (AY.43, AY.98 and AY.120) were found to display a statistically faster rate of spatial growth than the parent lineage and would seem to merit further investigation. We suggest that the monitoring of spatial growth rates is a potentially valuable adjunct to routine assessments of the growth of emerging SARS-CoV-2 lineages in a defined population.

 Lisään tähän hakutietoja  variantista AY.98 ja sen  ensimmäisestä alalinjasta. 9.2.2022 :

AY.98: omaa substituution E57  orf1a:ssa ja  deletion Orf8:ssa   (del119/120). Variantissa on 78%:ssa mutaatio  G142D.. Muuen  vaikutaa  koostumus  olevan kuin parent-deltassa. 

Alalinja poikkeaa vielä enemmän  parentdeltasta, mutta on myös menestynyt  5-6 kuukautta.

AY.98.1 omaa orf1a:ssa kaksi substituutiota, jotka ovat uusia: E87D ja E1724D.  Sitten sillä on spike-substituutio P251L, mutta  sillä ei ole G142D  mutaatiota. Orf f8 omaa  muutokset A65S, S84L ja deletio 119/120. 

Molempien varianttien käyrät ovat laskeneet  vuodenvaihteessa.  Analysoituja sekvenssejä on ollut  41,406 ja 32,974 vastaavasti.