Sars-2 ORF8 tekee interaktion PVR-proteiiniin ( poliovirusreseptoriin)

 https://www.genecards.org/cgi-bin/carddisp.pl?gene=PVR&keywords=PVR

 Sars-2 viruksen todettujen  interaktioproteiinien joukossa aivan  320 proteiinin listan alkupäässä on PVR. Tarkistan tänään siitä saatavat tiedot, koska  on niin paljon neurologisia oireita  Covid-19 taudin poteneilla, eikäkuitenkaan varsinaista viruksen kertymää neuroneissa ole osoitettu, vain plexus chorioideuksesta sanotaan siinä olevan runsaasti ACE2-reseptoria. Enkefalopatiset oireet ja todetut  konfuusiot  voivat tulla  kyllä  sitäkin tietä.

Mahdollisesti jokin nonstruktuuriproteiini kuten  ORF8 vaikutuksineen   voisi  selittää osan asioita. Katsotaan, mitä tietoa on.

 

Aliases for PVR Gene

• GeneCards Symbol: PVR ²
• PVR Cell Adhesion Molecule ^{2 3 5}
• Poliovirus Receptor ^{2 3 4}
• Necl-5 ^{2 3 5}
• CD155 ^{2 3 5}
• NECL5 ^{2 3 5}
• HVED ^{2 3 5}

• PVS ^{3 4 5}
• Nectin-Like Protein 5 ^{3 4}
• Tage4 ^{2 5}
• Nectin-Like 5 ²
• CD155 Antigen ⁴
• NECL-5 ⁴
• TAGE4 ³

Entrez Gene Summary for PVR Gene

• The protein encoded by this gene is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. The external domain mediates cell attachment to the extracellular matrix molecule vitronectin, while its intracellular domain interacts with the dynein light chain Tctex-1/DYNLT1. The gene is specific to the primate lineage, and serves as a cellular receptor for poliovirus in the first step of poliovirus replication. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

GeneCards Summary for PVR Gene

PVR (PVR Cell Adhesion Molecule) is a Protein Coding gene. Diseases associated with PVR include Poliomyelitis and Paralytic Poliomyelitis. Among its related pathways are Cell junction organization and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include signaling receptor activity and virus receptor activity. An important paralog of this gene is NECTIN2.

UniProtKB/Swiss-Prot Summary for PVR Gene

• Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytotoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration.

  • PVR_HUMAN,P15151
• (Microbial infection) Acts as a receptor for poliovirus. May play a role in axonal transport of poliovirus, by targeting virion-PVR-containing endocytic vesicles to the microtubular network through interaction with DYNLT1. This interaction would drive the virus-containing vesicle to the axonal retrograde transport.

  • PVR_HUMAN,P15151
• (Microbial infection) Acts as a receptor for Pseudorabies virus.

  • PVR_HUMAN,P15151
• (Microbial infection) Is prevented to reach cell surface upon infection by Human cytomegalovirus /HHV-5, presumably to escape immune recognition of infected cell by NK cells. 

  
  

  • PVR_HUMAN,P15151

  UniProtKB/Swiss-Prot Induction:

  Transcriptionally regulated by SHH.

  • PVR_HUMAN,P15151

  UniProtKB/Swiss-Prot BiophysicochemicalProperties:

  Kinetic parameters: KM=72 nM for VTN;

  • PVR_HUMAN,P15151

  GENATLAS Biochemistry:

  poliovirus sensitivity,receptor

  • PVR