Kirja HIV-viruksesta

Paul Spearman, Eric O.Freed ( Editors)
 Hiv Interactions with Host Cell proteins . 
Springer. Current Topics in Microbiology and Immunology. 2009, siis ei aivan tuoreinta tietoa. ISBN 978- 3- 642- 02174-9 Sivut 2004
Kirjan sisällöstä
Toimittajien alkulause 2009.
Kts. suomennoksia 23.2. 2015. 

(1) Vif  ja APOBEC3 

(2) Miten  HIV-viruksen lisäproteiini Vpu suhtautuu isäntäsolujen tekijöihin? Vpu ja Tetheriini
 Guatelli John C. Interactions of viral protein U (Vpu) and cellular factors ( Ss. 27-45)

(3) TRIMalfa proteiinit ovat  solun antiretrovirusjärjestelmää

(3)  Byeongwoon Song.  TRIM5alpha (Ss. 47- 66)
http://www.ncbi.nlm.nih.gov/pubmed?term=Byeongwoon%20Song.%20TRIM5alpha

 (4) HIV-1  Gag ja  isäntäsolun kalvorakkuloita kuljetattavat tiet 
(4) Chu Hin, Wang Jaang-Jiun, Spearman Paul. Human Immunodeficiency Virus type-1 Gag and host vesicular trafficking pathways (Ss. 67- 84)
http://www.ncbi.nlm.nih.gov/pubmed?term=Chu%20Hin%2C%20Wang%20Jaang-Jiun%2C%20Spearman%20Paul.%20Human%20Immunodeficiency%20Virus%20type-1%20Gag%20and%20host%20vesicular%20trafficking%20pathways

 (5) Mikä osuus on tetraspaniineilla  HIV-1 replikaatiossa?
(5) Thali Markus. The roles of tetraspanins in HIV-1 replication (Ss. 85- 102)
http://www.ncbi.nlm.nih.gov/pubmed?term=Thali%20Markus.%20The%20roles%20of%20tetraspanins%20in%20HIV-1%20replication

(6) Danielson Cindy M , Hope Thomas J. Imaging of HIV/Host protein Interaction (Ss. 103- 124)
http://www.ncbi.nlm.nih.gov/pubmed?term=Danielson%20Cindy%20M%20%2C%20Hope%20Thomas%20J.%20Imaging%20of%20HIV%2FHost%20protein%20Interaction

Abstract

HIV-1 relies on a myriad of interactions with host cell proteins to carry out its life cycle. Traditional biochemical approaches to probe protein-protein interactions are limited in their ability to study the spatial and dynamic interactions that take place in the context of an intact cell. However, issues such as localization and dynamics of interactions between viral and host proteins can be well addressed utilizing fluorescent imaging methods. The past decade has brought about the development of many novel fluorescent imaging techniques which have proved useful to describe the interaction of HIV-1 proteins with the host cell.

(7) Llano Manual, Morrison James, Poeschla Eric. M. Virological and Cellular Roles of the transcriptional coactivator LEDGF/p75 ( Ss. 125- 146)
http://www.ncbi.nlm.nih.gov/pubmed?term=Llano%20Manual%2C%20Morrison%20James%2C%20Poeschla%20Eric.%20M.%20Virological%20and%20Cellular%20

Roles%20of%20the%20transcriptional%20coactivator%20LEDGF%2Fp75

Abstract

The chromatin-associated cellular proteins LEDGF/p75 and LEDGF/p52 have been implicated in transcriptional regulation, cell survival and autoimmunity. LEDGF/p75 also appears to act as a chromatin-docking factor or receptor for HIV-1 and other lentiviruses and to play a role in leukemogenesis. For both the viral and cellular roles of this protein, a key feature is its ability to act as a molecular adaptor and tether proteins to the chromatin fiber. This chapter reviews the emerging roles of LEDGF/p75 and LEDGF/p52 in diverse cellular processes and disease states.

(8) Arhel Nathalie J, Kirchhoff. Implication of Nef: Host Cell interaction in viral persistence and progression to AIDS. (Ss. 147- 176)
http://www.ncbi.nlm.nih.gov/pubmed?term=Arhel%20Nathalie%20J%2C%20Kirchhoff.%20Implication%20of%20Nef%3A%20Host%20Cell%20interaction%20in%20viral%20persistence%20and%
20progression%20to%20AIDS.

Abstract

The HIV and SIV Nef accessory proteins are potent enhancers of viral persistence and accelerate progression to AIDS in HIV-1-infected patients and non-human primate models. Although relatively small (27-35 kD), Nef can interact with a multitude of cellular factors and induce complex changes in trafficking, signal transduction, and gene expression that together converge to promote viral replication and immune evasion. In particular, Nef recruits several immunologically relevant cellular receptors to the endocytic machinery to reduce the recognition and elimination of virally infected cells by the host immune system, while simultaneously interacting with various kinases to promote T cell activation and viral replication. This review provides an overview on selected Nef interactions with host cell proteins, and discusses their possible relevance for viral spread and pathogenicity.

(9) Planelles Vicente, Benichou Serge. Vpr and its interactions with cellular proteins (Ss. 177- 200)
http://www.ncbi.nlm.nih.gov/pubmed?term=Planelles%20Vicente%2C%20Benichou%20Serge.%20Vpr%20and%20its%20interactions%20with%20cellular%
20proteins

Abstract

Like most viral regulatory proteins, HIV-1 Vpr and homologous proteins from primate lentiviruses are small and multifunctional. They are associated with a plethora of effects and functions, including induction of cell cycle arrest in the G(2) phase, induction of apoptosis, transactivation, enhancement of the fidelity of reverse transcription, and nuclear import of viral DNA in macrophages and other nondividing cells. This review focuses on the cellular proteins that have been reported to interact with Vpr and their significance with respect to the known functions and effects of Vpr on cells and on viral replication.